EFFECTS OF PRENATAL EXPOSURE TO DIFFERENT SALT CONCENTRATIONS ON THE THIRD MONTH’S WEIGHT AND BLOOD PRESSURE IN WISTAR RAT
DOI:
https://doi.org/10.69656/pjp.v5i2.724Keywords:
Blood Pressure, Pregnancy, Prenatal, Rat, SaltAbstract
Background: In utero alterations in fluid and electrolyte endocrine systems may result in permanent effects on offspring. A low sodium intake during prenatal life jeopardizes growth in young rats, prenatal high-salt diet in Sprague-Dawley rats caused an increase in MAP at postnatal day 30. The objective of this study was to determine the effect of prenatal exposure to different salt concentrations on the third month’s weight and blood pressure in Wistar rat. Methods: This study was performed at the Department of Physiology, Isfahan University of Medical Science, Isfahan, Iran, over a period from 1998 to 2003. Six groups of rat, 1 male and 5 female in each group were exposed to 0.5, 1, 1.4, 1.6, 1.8 and 2 percent of salt concentrations during pre-pregnancy, pregnancy and lactation period, another test group consumed distilled water and control group used Isfahan tap water, other living conditions for all groups were similar. Exposure to different salt concentrations on the third month’s weight and blood pressure was evaluated. Results: Prenatal exposure to 0.5 and 1% salt concentrations gives birth to more alive and healthy infants, and third month’s weight increased significantly, but blood pressure was not influenced significantly. Salt concentrations higher than 1% increased the maternal and infant mortality rate and blood pressure significantly, but some concentrations decreased third month’s weight significantly. Conclusion: Level of dietary salt during intrauterine development can influence on the number of alive and healthy infants, birth weight, third month’ weight and blood pressure significantly. There is no need to introduce a salt restricted diet in prenatal care, a balanced diet in sodium during pregnancy is recommended, high salt diet creates harmful effect
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Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.