EFFECTS OF PRENATAL EXPOSURE TO DIFFERENT SALT CONCENTRATIONS ON THE THIRD MONTHâ€™S WEIGHT AND BLOOD PRESSURE IN WISTAR RAT
Keywords:Blood Pressure, Pregnancy, Prenatal, Rat, Salt
Background: In utero alterations in fluid and electrolyte endocrine systems may result in permanent effects on offspring. A low sodium intake during prenatal life jeopardizes growth in young rats, prenatal high-salt diet in Sprague-Dawley rats caused an increase in MAP at postnatal day 30. The objective of this study was to determine the effect of prenatal exposure to different salt concentrations on the third monthâ€™s weight and blood pressure in Wistar rat. Methods: This study was performed at the Department of Physiology, Isfahan University of Medical Science, Isfahan, Iran, over a period from 1998 to 2003. Six groups of rat, 1 male and 5 female in each group were exposed to 0.5, 1, 1.4, 1.6, 1.8 and 2 percent of salt concentrations during pre-pregnancy, pregnancy and lactation period, another test group consumed distilled water and control group used Isfahan tap water, other living conditions for all groups were similar. Exposure to different salt concentrations on the third monthâ€™s weight and blood pressure was evaluated. Results: Prenatal exposure to 0.5 and 1% salt concentrations gives birth to more alive and healthy infants, and third monthâ€™s weight increased significantly, but blood pressure was not influenced significantly. Salt concentrations higher than 1% increased the maternal and infant mortality rate and blood pressure significantly, but some concentrations decreased third monthâ€™s weight significantly. Conclusion: Level of dietary salt during intrauterine development can influence on the number of alive and healthy infants, birth weight, third monthâ€™ weight and blood pressure significantly. There is no need to introduce a salt restricted diet in prenatal care, a balanced diet in sodium during pregnancy is recommended, high salt diet creates harmful effect
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