EFFECT OF FEEDING WITH DIFFERENT SALT CONCENTRATIONS IN PRENATAL PERIOD ON THE VASCULAR RESPONSE TO EPINEPHRINE AND ACETYLCHOLINE

  • Heydarpour Fereidoun Department of Physiology, Zanjan University of Medical Sciences, Zanjan
  • Rostami Ahmad Department of Physiology
  • Sobhan Ahmad Department of Pathology, Isfahan University of Medical Sciences, Isfahan
  • Heydarpour Pouria Medical Faculty, Tehran University of Medical Science, Tehran, Iran
Keywords: Prenatal care, Sodium Chloride, Blood Pressure, Acetylcholine, Epinephrine

Abstract

Background: Determine the effect of prenatal exposure to different salt concentrations on the third month’s blood pressure and vascular response to epinephrine and acetylcholine. Methods: Eight groups of rat, six in each group, one male and five female were exposed to different salt concentrations, Isfahan tap water and distilled water during pre-pregnancy, pregnancy and lactation period. After blood pressure measurement in infants, in one sub-group 1% body weight of blood was substituted by the same volume of NaCl 0.9% containing 1 µg/ml epinephrine and in the other group by 0.1 µg/ml acetylcholine. Results: Salt concentrations higher than 1% increased third month’s blood pressure and vascular response to epinephrine and decreased vascular response to acetylcholine while lower salt concentrations had no significant influence. Conclusion: Level of dietary salt during intrauterine development can permanently alter the mechanisms that regulate cardiovascular function, blood pressure and vascular response to epinephrine and acetylcholine.

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Published
2011-06-30
How to Cite
1.
Fereidoun H, Ahmad R, Ahmad S, Pouria H. EFFECT OF FEEDING WITH DIFFERENT SALT CONCENTRATIONS IN PRENATAL PERIOD ON THE VASCULAR RESPONSE TO EPINEPHRINE AND ACETYLCHOLINE. PJP [Internet]. 30Jun.2011 [cited 27Jul.2021];7(1):8-2. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/762