EFFECT OF THIAZOLIDINEDIONE TREATMENT ON RESISTIN LEVELS IN INSULIN RESISTANT SPRAGUE DAWLEY RATS

Authors

  • Iftekhar Yousaf Assistant Professor Physiology, Army Medical College, Rawalpindi.
  • Waqas Hameed Pak International Medical College, Peshawar
  • Tauseef Ahmed Rajput Margalla Institute of Health Sciences, Rawalpindi

Keywords:

resistin, adipocytokines, insulin resistance, type 2 diabetes, HDL

Abstract

Insulin resistance is manifested by decreased effect of fixed quantity of insulin on glucose metabolism leading to type 2 diabetes mellitus. Visceral obesity has been positively correlated with insulin resistance but its mechanism is not fully defined. Insulin resistance may be the consequence of adipocytokines including visfatin and resistin. This study was designed to see the effect of thiazolidinediones on levels of resistin in insulin resistant rats. Methods: Ninety Sprague Dawley rats were randomly divided into three groups. Group I served as control. Rats in Group II and III were made insulin resistant diabetics. Group III was treated with rosiglitazone after development of diabetes. Plasma glucose, serum triglycerides, HDL, TG:HDL ratio and serum resistin levels were analysed. Results: Body weight and plasma glucose were significantly increased (p<0.05) along with TG:HDL ratio (p<0.05) in group II and group III at the end of 4th week. Serum resistin levels also increased significantly (p<0.05) in group II and III at the end of 4th week. Treatment of group III with rosiglitazone led to improvement in insulin resistance with decrease in serum resistin levels (p<0.05). Conclusion: Increased serum resistin level indicates insulin resistance and impending hyperglycaemia. Thiazolidinediones augment sensitivity of insulin to restore normoglycaemia by decreasing serum resistin level. 

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Published

30-06-2015

How to Cite

1.
Yousaf I, Hameed W, Rajput TA. EFFECT OF THIAZOLIDINEDIONE TREATMENT ON RESISTIN LEVELS IN INSULIN RESISTANT SPRAGUE DAWLEY RATS. Pak J Phsyiol [Internet]. 2015 Jun. 30 [cited 2024 Jun. 22];11(2):8-10. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/390