ROLE OF TRPM6 AND TRPM7 GENE POLYMORPHISMS IN RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW

Authors

  • Shahid Fareed Accident and Emergency Department, Lady Reading Hospital, Peshawar
  • Shah Hussain Accident and Emergency Department, Lady Reading Hospital, Peshawar.
  • Farooq Khan Department of Anatomy, Peshawar Medical College, Peshawar
  • Jehan Badshah Emergency Department, Lady Reading Hospital, Peshawar.
  • Fateh ur Rehman Rufaidah Nursing College, Peshawar.
  • Mohsin Ali Muhammad College of Medicine, Peshawar, Pakistan

DOI:

https://doi.org/10.69656/pjp.v18i1.1365

Keywords:

Rheumatoid arthritis, TRPM6, TRPM7, Peshawar, hypomagnesemia, Arthritis, Magnesium, Polymorphism

Abstract

Rheumatoid arthritis (RA) is a type of the autoimmune disease that adversely effects on the quality of life of the patient, primarily by affecting the joints. Different underlying immune system diseases through a common pathway may proceed to onset of rheumatoid arthritis. Magnesium (Mg) is one of the other essential minerals having significant role in the management of normal immune responses in inflammatory conditions. The exact role of magnesium deficiency (MgD) in pathophysiology of rheumatoid arthritis is still under debate, but several mechanisms are proposed through which, MgD leads to generation of inappropriate immune system functions. Most of the dietary Mg is absorbed in small intestine through paracellular passive mechanism while small amount is transported in blood through Transient Receptor Potential Channel Melastatin member 6 and 7 (TRPM6 and TRPM7). Genetic alterations in TRPM gene results in hypomagnesaemia, which may in turn, increase the risk of onset of pro-inflammatory mediators.

Pak J Physiol 2022;18(1):63–7

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Published

31-03-2022

How to Cite

1.
Fareed S, Hussain S, Khan F, Badshah J, Rehman F ur, Ali M. ROLE OF TRPM6 AND TRPM7 GENE POLYMORPHISMS IN RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW. Pak J Phsyiol [Internet]. 2022 Mar. 31 [cited 2024 Nov. 23];18(1):63-7. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1365

Issue

Vol. 18 No. 1 (2022): Pakistan Journal of Physiology

Section

Review Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.