GLUCOSE LOWERING EFFECT OF VISFATIN IN OBESE AND INSULIN DEPENDENT DIABETES MELLITUS

  • Muhammad Mazhar Hussain Department of Physiology, Army Medical College, Rawalpindi
  • Raeesa Naz Department of Physiology, Army Medical College, Rawalpindi
  • Waqas Hameed Department of Physiology, Army Medical College, Rawalpindi
  • Muhammad Aslam Shifa College of Medicine, Islamabad, Pakistan
Keywords: Visfatin, obesity, adipocytokines, insulin dependent diabetes mellitus

Abstract

Background: Human obesity-related diabetes and the accompanying metabolic disorders have been specifically linked to increased visceral adipose tissue mass. Visfatin (pre-B-cell colony enhancing factor, PBEF) is a novel adipokine that appears to be preferentially produced by visceral adipose tissue that has insulin-mimetic actions. This study investigated if visfatin administration decreases blood glucose in both obese and insulin dependent diabetic mice. Methods: One hundred and twenty balb/c strain albino mice were divided into 4 groups. Animals in Group I and Group II were made obese by feeding high fat/high carbohydrate diet whereas Group III and Group IV were made insulin dependent diabetic by injecting streptozotocin. Group I and Group III served as controls whereas Group II and Group IV were administered visfatin injection intravenously as a single bolus dose. Blood samples were collected to measure the blood glucose and visfatin levels. Results: Visfatin levels were found increased in obese mice, while administration of recombinant-histidine soluble (mice) visfatin significantly decreased the blood glucose level in obese and insulin dependent diabetic mice (p<0.001). Conclusion: The glucose lowering effect of visfatin in insulin resistant and insulin dependent diabetic mice is observed.

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Published
2011-06-30
How to Cite
1.
Hussain M, Naz R, Hameed W, Aslam M. GLUCOSE LOWERING EFFECT OF VISFATIN IN OBESE AND INSULIN DEPENDENT DIABETES MELLITUS. PJP [Internet]. 30Jun.2011 [cited 27Jul.2021];7(1):4-. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/756