SMOKING IS RELATED TO ALBUMIN EXCRETION IN TYPE 2 DIABETES MELLITUS

Abstract

Background: Smoking is related to premature development of multiple complications of diabetes mellitus and it also increases the risk for albuminuria type 2 diabetes mellitus. So, present study was carried out to determine the association between smoking and albumin excretion in patients with type 2 diabetes mellitus. Methods: A cross sectional analytical study conducted on patients with type 2 diabetes mellitus during 2004 at Jinnah Postgraduate Medical Center Karachi. Study population included 75 patients of type 2 diabetes mellitus (50 men, 25 women) from diabetic clinic Jinnah Postgraduate Medical Center Karachi 25 non diabetics (15 men, 10 women) from general population as control. Each subject was interviewed, examined, and investigated for blood pressure measurements, body mass index, fasting serum glucose, urinary volume, urinary albumin,
urinary albumin excretion rate, and smoking years. Patients having clinical albuminuria and with other causes of proteinuria were excluded. Results: Albumin excretion was highly significant (p< 0.001) in smoker type 2 diabetics as compared to smoker non diabetics. Similarly, albuminuria was increased (p<0.001) in smoker type 2 diabetics in comparison with non smoker type 2 diabetics. A significant correlation was found between years of smoking and albuminuria (r= 0.448, p<0.05) in smoker type 2 diabetics. Conclusion: Albumin excretion correlates with smoking in type 2 diabetics.