SERUM HOMOCYSTEINE CONCENTRATIONS IN PATIENTS WITH HYPERTENSION

Authors

  • Alina Atif Department of Physiology, Dow Medical College, Dow University of Health Sciences. Karachi
  • Muhammadi Atif Rizvi Department of Physiology, Dow Medical College, Dow University of Health Sciences. Karachi.
  • Shoaib Tauheed Department of Physiology, Dow Medical College, Dow University of Health Sciences. Karachi.
  • Irum Aamir Department of Physiology, Dow Medical College, Dow University of Health Sciences. Karachi
  • Farrukh Majeed Department of Physiology, Dow Medical College, Dow University of Health Sciences. Karachi.
  • Khalid Siddiqui Department of Physiology, Dow Medical College, Dow University of Health Sciences. Karachi.
  • Sadaf Khan Department of Physiology, Dow Medical College, Dow University of Health Sciences. Karachi.

DOI:

https://doi.org/10.69656/pjp.v4i1.654

Keywords:

Homocysteine, Hypertension, Blood Pressure

Abstract

Elevated plasma homocysteine is a known risk factor for atherosclerotic vascular disease. In fact, it is an independent risk factor similar to smoking or hyperlipidemia but it is under recognized among the doctors of Pakistan. An elevated homocysteine level induces thrombogenicity, causes procoagulant state and promotes the proliferation of smooth muscle cells. This study was carried out to find out the serum homocysteine levels in patients with known hypertension. Methods: One hundred patients more than 60 years of age of both the sexes with documented hypertension were selected from medical wards and cardiology ward of Civil Hospital Karachi. Study subjects had no history of atherosclerotic disease or diabetes mellitus. Homocysteine estimation was done by FPIA method on IMX. Results: It was seen that 80% patients selected had an elevated homocysteine levels (18.77±1.9 as against 5–15 taken as normal). Conclusion: We have observed that serum homocysteine is raised in most of the patients with hypertension.

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Published

30-06-2008

How to Cite

1.
Atif A, Rizvi MA, Tauheed S, Aamir I, Majeed F, Siddiqui K, et al. SERUM HOMOCYSTEINE CONCENTRATIONS IN PATIENTS WITH HYPERTENSION. Pak J Phsyiol [Internet]. 2008 Jun. 30 [cited 2024 Dec. 3];4(1):21-2. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/654

Issue

Vol. 4 No. 1 (2008): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.