NON HIGH DENSITY LIPOPROTEIN CHOLESTEROL IN TYPE 2 DIABETES MELLITUS

Abstract

Background: Dyslipidemia consisting of elevated triglyceride, decreased HDL, and low-density lipoproteins LDL particles of altered composition is an important cardiovascular disease (CVD) risk factor in individuals with type 2 diabetes mellitus. Measure of Non-HDL cholesterol might be a useful marker of this risk. Presuming the value of non-HDL cholesterol we intend to determine whether non-HDL cholesterol, a measure of total cholesterol minus HDL cholesterol is elevated in patients with type 2 diabetes mellitus. Methods: Study population comprised of 60 patients of type 2 diabetes mellitus (24 men, 36 women) from diabetic clinic Jinnah Postgraduate Medical Center Karachi. Each subject was interviewed, examined, and investigated for blood pressure measurements, body mass index, and fasting blood glucose.  Blood sample was analyzed to determine serum total cholesterol and HDL cholesterol on auto analyzer after at least a 12-h overnight fast. Results: The level of non-HDL cholesterol was elevated significantly (p<0.01) in hypertensive patients of type 2 diabetes in contrast to normotensive patients of same disease, while HDL cholesterol shows significant decrease (29.46*±6.55) in hypertensive diabetics as compared to normotensive diabetics (34.43 ±9.44). Conclusion: Non–HDL cholesterol was elevated in type 2 diabetics who suffering from hypertension