COMPARISON OF THE EFFECT OF SYMPATHETIC AGONIST AND ANTAGONIST ON RABBITS PERFUSED HEART: A STUDY ON SIMPLE AND SUCCUSSED DILUTIONS

Abstract

Background: The pharmacological effect of Adrenaline and Atenolol dilutions/succussion is still unexplainable for their reverse effect on tissues. This effect of potentization is observed in the recent study with differences in the effect of simple and succussed dilutions on heart rate. Methods: For this purpose, both simple and succussed dilutions of Adrenaline & Atenolol were prepared serially, ranging from 10-3 to 10-36 for testing on the isolated perfused Rabbit’s heart. Langendorff heart assembly was used to perfuse the heart and its activity was recorded on Oscillograph through isotonic transducer. Results: The significant difference between the effects of simple and succussed dilutions of Adrenaline at 10-3 and 10-4 and for Atenolol 10-5, 10-11, 10-27,
10-30, 10-33 and 10-36 was observed on heart rate respectively. Conclusion: This study confirms that there are differences in the effects of simple & succussed dilutions. While, potentization or reverse effect observed than normal has been found in-consistently throughout the range of dilutions used. Thus in-consistency expresses the instability of change in parent drug molecule on succussion.