EFFECTS OF PROLONGED ADMINISTRATION OF LARGE DOSES OF ACTH ON BUFO MELANOSTICTUS TADPOLES

Authors

  • Mahmood Ahmed Department of Physiology, University of Karachi.
  • Ruqaiya Hasan Department of Physiology, University of Karachi, Karachi Pakistan
  • Mansoor Ahmad New York Medical College Valhalla, N.Y U.S.A.

Keywords:

Tadpole, ACTH, Growth

Abstract

The present study reports the effects of different ACTH preparations, in similar and different concentrations on Bofo Melanostictus Tadpoles. Results: ACTH administration proved antagonistic to tadpole growth hormone. There seemed to be no dose-effect response when ACTH was administered in 0.02 IU/ml instead of 0.01 IU/ml. Similar ACTH concentrations with difference of manufacture showed varied biological potency. Conclusions: This perhaps indicates loss of effectiveness due to change from ACTH 1–24 to ACTH 1–18 to ACTH 1–10 in descending order.

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Published

21-05-2018

How to Cite

1.
Ahmed M, Hasan R, Ahmad M. EFFECTS OF PROLONGED ADMINISTRATION OF LARGE DOSES OF ACTH ON BUFO MELANOSTICTUS TADPOLES. Pak J Phsyiol [Internet]. 2018 May 21 [cited 2024 Jun. 22];1(1-2). Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/576