RESPIRATORY FUNCTIONS IN ASTHMATIC AND NORMAL WOMEN DURING DIFFERENT PHASES OF MENSTRUAL CYCLE

Authors

  • Dimple Bajaj Arora Department of Physiology, Sri Guru Ramdas Institute of Medical Sciences and Research (SGRDIMSAR), Amritsar , Punjab, India.
  • Parminder Kaur Sandhu Department of Physiology, Sri Guru Ramdas Institute of Medical Sciences and Research (SGRDIMSAR), Amritsar
  • Sukhjinder Dhillon Department of Physiology, Sri Guru Ramdas Institute of Medical Sciences and Research (SGRDIMSAR), Amritsar
  • Anterpreet Arora Department of Anatomy, Sri Guru Ramdas Institute of Medical Sciences and Research (SGRDIMSAR), Amritsar
  • Nimarpreet Kaur Department of Physiology, SHKM Govt Medical College, Nalhar, Mewat, India

Keywords:

Menstrual cycle, Pulmonary functions, Asthma, Progesterone, Oestrogen

Abstract

Background: Menstrual cycle is an integral part of life of women. There is widespread agreement that changes in the levels of oestrogen and progesterone associated with menstrual cycle also affect different systems of the body besides reproductive system. Levels of oestrogen and progesterone are maximum in the secretory phase and minimum just before the menstruation .Bronchial asthma is one of the commonest chronic respiratory diseases. Premenstrual worsening of asthma symptoms has been reported to affect 33–40% of asthmatic women. This exacerbation of asthma symptoms has been correlated with the oestrogen and progesterone levels. The association between menstrual cycle and lung functions in normal females has also been recognised. The pathophysiology of this process is still not proved. The purpose of our study was to confirm the probable effects of the female hormones on lung functions in normal and asthmatic women in different phases of menstrual cycle and to compare them. Methods: The study was done on 40 normal and 40 asthmatic females in the age group of 15–45 years. Pulmonary function tests were done in three phases of menstrual cycle i.e. follicular, secretory and menstrual in all the subjects. Results: The mean value of lung functions, i.e., FVC, FEV, PEFR, FEF25–75%, FEF200–1200 were significantly lower in asthmatic females than normal ones (p<0.01) in all three phases. The lung functions of both asthmatic and non-asthmatic females in secretory phase were significantly higher than in menstrual phase (p<0.005). The PFTs in menstrual phase were even lower than the follicular phase (p<0.04). Conclusion: Respiratory parameters of both asthmatic and non-asthmatic women in reproductive age group show significant variation in different phases of menstrual cycle. The smooth muscle relaxant effect of progesterone and probably oestrogen might have contributed to it. The lung function parameters in asthmatics were of lower value compared to normal women.

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References

1. Nowak RM, Hurd SS, Skobeloff EM, Taggart VS. Future directions of emergency medicine. Ann Emerg Med 1996;27(2):244–9.
2. O’Connor BJ. Premenstrual asthma: still poorly understood. Thorax 1997;52(7):608–11.
3. Karpel JP, Wait JL. Asthma in women, part-3: Perimenstrual asthma, effects of hormonal therapy. J Crit Illness 2000;15:265–72.
4. Zimmerman JL, Woodruff PG, Clark S, Camargo CA. Relation between phase of menstrual cycle and emergency department visits for acute asthma. Am J Respir Crit Care Med 2000;162:512–5.
5. Skobeloff EM, Spivey WH, Silverman R, Eskin BA, Harchelroad F, Alessi TV. The effect of menstrual cycle on asthma presentations in the emergency department. Arch Int Med 1996;156(16):1837–40.
6. Rao GS, Rajan P, Walter S. Expiratory flow rate changes during the menstrual cycle. Indian J Physiol Pharmacol 1991;35(1):74–76.
7. Standardisation of Spirometry. American Thoracic Society, 1994 update. Am J Respir Crit Care Med 1994;152:1107–36.
8. Rajesh CS, Gupta P, Vaney N. Status of pulmonary function tests in adolescent females of Delhi. Indian J Physiol Pharmacol 2000;44(4):442–8.
9. Beynon HL, Garbett ND, Barnes PJ. Severe premenstrual exacerbation of asthma: effect of intramuscular progesterone. Lancet 1988;2(8607):370–2.
10. Chandler MH, Schuldheisz S, Phillips BA, Muse KN. Premenstrual asthma: the effect of estrogen on symptoms, pulmonary functions and beta-2 receptors. Pharmacotherapy 1997;17(2):224–34.
11. Rumball J. Understanding the relationship between asthma and menstrual cycle. Western J Graduate Res 2001;10(1):65–8.
12. Rao VSJ, Shah A, Nanal N. Pulmonary function tests in asthma. Indian J Clin Practice.1994; (Specialty issue on Asthma and Allergy) July:1–3.
13. Weinberger SE, Drazen JM. Disturbances in respiratory function. Harrison’s Principles of Internal Medicine, 15th ed. 2001;1446–56.
14. Pai SR, Prajna P. A correlative study on blood pressure and lung function profile during different phases of menstrual cycle among Indian population. Indian J Physiol Sci 2001;33:81–5.

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Published

30-06-2015

How to Cite

1.
Arora DB, Sandhu PK, Dhillon S, Arora A, Kaur N. RESPIRATORY FUNCTIONS IN ASTHMATIC AND NORMAL WOMEN DURING DIFFERENT PHASES OF MENSTRUAL CYCLE. Pak J Phsyiol [Internet]. 2015 Jun. 30 [cited 2024 Jun. 22];11(2):3-7. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/380