PREPARE FOR ANOTHER HOTTER SUMMER THAT MAY IMPACT YOUR HEALTH
DOI:
https://doi.org/10.69656/pjp.v22i2.1963Keywords:
Heat shock proteins, Heat stress, Heat strokeAbstract
Globally next few years will be hotter than before. Heat wave is expected in Pakistan also. Heat stress is the leading cause of weather-related deaths and can exacerbate underlying illnesses including cardiovascular disease, diabetes, mental health, asthma. Heat stroke is a medical emergency with a high-case fatality rate. Infants and elderly persons are more prone to temperature changes. Above environmental temperature around 33–35 °C heat stress begins. When the body experiences heat stress and body temperature rises beyond normal, cells release heat shock proteins (HSP) that can trigger inflammatory responses mediated by cytokines. This process contributes to endothelial damage, vasodilation, and widespread cell death, resulting in potential organ damage. When an unacclimatized person is exposed to extreme heat for prolonged time, the person may suffer heat exhaustion or heat stroke. Heat Exhaustion is a heat-related illness caused by excessive sweating, which leads to loss of water and electrolytes and a decreased blood volume. Without replacement of water and electrolytes, this will lead to decreased arterial pressure and feelings of dizziness, muscle cramps, and fainting. Heat exhaustion, if untreated, can lead to heat stroke. WHO and NDMA advised that people should drink water frequently, especially when going outside; avoid heat exposure by limiting outdoor activities between 10 am to 04 pm; use light coloured and loose-fitting clothes; never leave children in parked vehicles.
Pak J Physiol 2026;22(2):71–2, DOI: https://doi.org/10.69656/pjp.v22i2.1963
Downloads
References
Madge G. 2026 outlook: likely another year above 1.4 °C. https://www.metoffice.gov.uk/about-us/news-and-media/media-centre/weather-and-climate-news/2025/2026-outlook-likely-another-year-above-1.4c#:~:text=The%20average%20global%20temperature%20for,C%20above%20pre%2Dindustrial%20levels. [Accessed: 23-4-2026]
Pakistan Meteorological Department. Warning of severe heat waves across the country, creating significant health risks. https://www.accuweather.com/en/pk/lahore/260622/july-weather/260622#:~:text=According%20to%20AccuWeather%2C%20the%20average%20high%20temperature,or%20two%20with%20a%20high%20of%2099%C2%B0 [Accessed: 23-4-2026]
World Health Organization. Heat and Health. https://www.who.int/news-room/fact-sheets/detail/climate-change-heat-and-health. [Accessed: 28-4-2026]
Hall JE, Hall ME. Body temperature regulation and fever. In: Guyton and Hall Textbook of Medical Physiology. 15th ed. Philadelphia: Elsevier; 2025. pp 923–34.
Barrett KE, Barman SM, Brooks HL, Yuan JX-J, (Editors).. Ganong’s Review of Medical Physiology. 26th ed. New York: McGraw-Hill Education; 2019.
Centers for Disease Control and Prevention (CDC). (2022).* Heat Stress—Hydration and Acclimatization. National Institute for Occupational Safety and Health (NIOSH).
Perez RI, Londono MJ, Everitt B, Young D, Hood RL, De Lorenzo RA, McDermott BP. Exertional and classic heat stroke: A narrative review. Am J Emerg Med 2026;102:49–54. doi: 10.1016/j.ajem.2026.01.008. [Accessed: 27-4-2026]
Leon LR, Bouchama A. Heat stroke: Role of the systemic inflammatory response. J Appl Physiol 2010;109(6):1980–8.
WHO’s “Beat the Heat” initiative making strides to protect workers and event participants from extreme heat and related environmental hazards. https://www.who.int/news/item/12-06-2025-who-s--beat-the-heat--initiative-making-strides-to-protect-workers-and-event-participants-from-extreme-heat-and-related-environmental-hazards [Accessed: 14-4-2026]
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Tehseen Iqbal

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
The author(s) retain the copyrights and allow their publication in Pakistan Journal of Physiology/Pak J Physiol/PJP to be FREE for research and academic purposes. It can be downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.











