RELATIONSHIP OF OBESITY WITH INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME
Background: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, hyper-insulinemia and obesity. This study was designed to find out the levels of insulin resistance (IR) and its relationship with obesity in patients of PCOS. Methods: Seventy-four (74) females, diagnosed as PCO were selected from the Outpatient Department of Lady Atchison Hospital and divided in two groups. Group 1, PCOS with BMI <25 Kg/m2 and Group 2 with BMI â‰¥25 Kg/m2. Blood glucose and serum insulin were determined using ELISA. Insulin resistance was calculated using HOMA-IR method. Data was analyzed using SPSS-20. MeanÂ±SD was used to present quantitative data. Normality of data was checked by one sample Kolmogorov Simonov test. Pearsonâ€™s correlation test was applied to see relationship between insulin resistance and obesity. The pâ‰¤0.05 was considered as significant. Results: Serum insulin in Group 2 (26.35Â±25.78) was statistically higher than Group 1 (16.63Â±13.58). Insulin resistance in Group 2 and Group 1 was 5.37Â±4.96 and 4.25Â±3.53 respectively, with no statistically significant difference (p=0.249). No significant correlation was found between IR and BMI in either cases or controls but overall a weak positive correlation was noted between the two variables. Conclusion: Insulin resistance and serum insulin were higher in females with polycystic ovarian syndrome. Insulin resistance and hyperinsulinaemia share the disease and might exacerbate the symptoms of disease. No significant correlation was found between insulin resistance and BMI
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