RELATIONSHIP OF OBESITY WITH INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME

Authors

  • Imrana Ihsan Qazi
  • Asma Tehreem Qazi
  • Farhat Ijaz
  • Samia Jawed
  • Rana Khurram Aftab Physiology department, KEMU
  • Shafia Rasool Qazi

DOI:

https://doi.org/10.69656/pjp.v14i3.196

Keywords:

Polycystic Ovary Syndrome, Insulin Resistance, Obesity, PCOS

Abstract

Background: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, hyper-insulinemia and obesity. This study was designed to find out the levels of insulin resistance (IR) and its relationship with obesity in patients of PCOS. Methods: Seventy-four (74) females, diagnosed as PCO were selected from the Outpatient Department of Lady Atchison Hospital and divided in two groups. Group 1, PCOS with BMI <25 Kg/m2 and Group 2 with BMI ≥25 Kg/m2. Blood glucose and serum insulin were determined using ELISA. Insulin resistance was calculated using HOMA-IR method. Data was analyzed using SPSS-20. Mean±SD was used to present quantitative data. Normality of data was checked by one sample Kolmogorov Simonov test. Pearson’s correlation test was applied to see relationship between insulin resistance and obesity. The p≤0.05 was considered as significant. Results: Serum insulin in Group 2 (26.35±25.78) was statistically higher than Group 1 (16.63±13.58). Insulin resistance in Group 2 and Group 1 was 5.37±4.96 and 4.25±3.53 respectively, with no statistically significant difference (p=0.249). No significant correlation was found between IR and BMI in either cases or controls but overall a weak positive correlation was noted between the two variables. Conclusion: Insulin resistance and serum insulin were higher in females with polycystic ovarian syndrome. Insulin resistance and hyperinsulinaemia share the disease and might exacerbate the symptoms of disease. No significant correlation was found between insulin resistance and BMI

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References

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Pak J Physiol 2018;14(3)

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Published

20-08-2018

How to Cite

1.
Qazi II, Qazi AT, Ijaz F, Jawed S, Aftab RK, Qazi SR. RELATIONSHIP OF OBESITY WITH INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME. Pak J Phsyiol [Internet]. 2018 Aug. 20 [cited 2024 Nov. 21];14(3):46-9. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/196

Issue

Vol. 14 No. 3 (2018): Pakistan Journal of Physiology

Section

Original Article

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Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.