DISPARATE RELATIONSHIP OF VITAMIN D RECEPTOR CDX2 GENE POLYMORPHISM AND POLYCYSTIC OVARIAN SYNDROME IN FEMALES OF SINDH, PAKISTAN

Authors

  • Soubia Malik Department of Physiology, University of Karachi
  • Aliya Maqsood Department of Physiology, University of Karachi
  • Mehir un Nisa Iqbal
  • Taseer Ahmed Khan Department of Physiology, University of Karachi

DOI:

https://doi.org/10.69656/pjp.v14i4.165

Keywords:

VDR, PCOS, Cdx2, T-ARMS, PCR, SNP

Abstract

Background: Vitamin D regulates various biological processes and its role in the pathogenesis of Polycystic Ovarian Syndrome (PCOS) is still dubious. Vitamin D receptor (VDR) Cdx2 polymorphism is located in the promoter area of VDR gene, it’s A allele increases and G allele decreases transcription and might play role in the development of insulin resistance in PCOS. Therefore, the rationale of present study was to investigate the relationship between VDR Cdx2 gene polymorphism and PCOS among young females of Pakistan.

Methods: A total of 175 subjects (80 cases and 95 controls) were enrolled in this study. Blood samples were collected and genomic DNA was isolated. Genotyping of VDR Cdx2 was carried out using tetra-primer amplification refractory mutation system (T-ARMS) PCR technique.

Results: Results showed a significant association (χ2= 9.640 P-value= 0.008) among PCOS and VDR-Cdx2 variant with no risk obtained in GG and GA genotypes of VDR Cdx2.

Conclusion:  VDR Cdx2 gene polymorphism may be associated with PCOS.

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Author Biographies

Mehir un Nisa Iqbal

Mehir un Nisa Iqbal (PhD)

Assistant Professor

 Department of Physiology

University of Karachi

Taseer Ahmed Khan, Department of Physiology, University of Karachi

Taseer Ahmed Khan (PhD)

Associate professor

Department of Physiology 

University of Karachi

 

Pak J Physiol 2018;14(4)

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Published

31-12-2018

How to Cite

1.
Malik S, Maqsood A, Iqbal M un N, Khan TA. DISPARATE RELATIONSHIP OF VITAMIN D RECEPTOR CDX2 GENE POLYMORPHISM AND POLYCYSTIC OVARIAN SYNDROME IN FEMALES OF SINDH, PAKISTAN. Pak J Phsyiol [Internet]. 2018 Dec. 31 [cited 2024 Dec. 22];14(4):18-20. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/165

Issue

Vol. 14 No. 4 (2018): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.