PREVALENCE OF CARDIAC AUTONOMIC NEUROPATHY AMONG TYPE 2 DIABETICS AT A TERTIARY CARE CENTRE

Authors

  • Muhammad Ishfaq Associate Professor of Medicine, Khyber Girls Medical College, Peshawar
  • Sadiq Saleem Department of Medicine, Hayatabad Medical Complex, Peshawar
  • Imran Qadir Specialist Registrar Medicine, Hayatabad Medical Complex, Peshawar
  • Amanullah Assistant Professor, Department of Physiology, Swat Medical College, Swat
  • Saima Akbar Hayatabad Medical Complex, Peshawar
  • Sidra Humayun Department of Pathology, Muhammad College of Medicine Peshawar, Pakistan

DOI:

https://doi.org/10.69656/pjp.v20i2.1623

Keywords:

Type 2 Diabetes Mellitus, Cardiac autonomic neuropathy, Cardiovascular disease, Hypertension

Abstract

Background: In the context of Type 2 diabetes mellitus (T2DM), the frequency of cardiac autonomic neuropathy has become a subject of intensive research. Understanding the prevalence and associated risk factors is pivotal for early detection, intervention, and improved patient outcomes. The objective of this study was to assess the prevalence of cardiac autonomic neuropathy in individuals with type 2 diabetes mellitus at a Hayatabad Medical Complex Peshawar. Methods: This cross-sectional study was conducted at Department of Medicine, Hayatabad Medical Complex, Peshawar, from 16th Nov 2022 to 16 May 2023 on patients presenting with type 2 diabetes in the age group 20?75 years. Pregnant women, patients with end-stage renal disease and neurological abnormalities were excluded. The frequency of cardiac autonomic neuropathy (CAN) was determined. Results: There was a total of 260 patients presenting with type 2 Diabetes mellitus during the study period. The mean age of the patients was 50.36±15.56 years. The frequency of cardiac autonomic neuropathy was 92 (35.4%), 62 were male and 30 were female. Conclusion: Cardiac autonomic neuropathy is a common micro-vascular complication in T2DM with duration of diabetes, age, and other microvascular complications being the significant contributors to its pathogenesis and severity.

Pak J Physiol 2024;20(2):11-3

Downloads

Download data is not yet available.

References

Azeem S, Khan U, Liaquat A. The increasing rate of diabetes in Pakistan: A silent killer. Ann Med Surg 2022;79:103901.

Dimitropoulos G, Tahrani AA, Stevens MJ. Cardiac autonomic neuropathy in patients with diabetes mellitus. World J Diabetes 2014;5(1):17–39.

Jyotsna F, Ahmed A, Kumar K, Kaur P, Chaudhary MH, Kumar S, et al. Exploring the complex connection between diabetes and cardiovascular disease: analyzing approaches to mitigate cardiovascular risk in patients with diabetes. Cureus 2023;15(8):e43882.

Spallone V. Update on the impact, diagnosis and management of cardiovascular autonomic neuropathy in diabetes: what is defined, what is new, and what is unmet. Diabetes Metab J 2019;43(1):3–30.

Sharma JK, Rohatgi A, Sharma D. Diabetic autonomic neuropathy: a clinical update. J R Coll Physicians Edinb 2020;50(3):269–73.

Agashe S, Petak S. Cardiac autonomic neuropathy in diabetes mellitus. Methodist Debakey Cardiovasc J 2018;14(4):251–6.

Prasad DS, Kabir Z, Revathi Devi K, Peter PS, Das BC. Prevalence and risk factors for silent myocardial ischemia (PRISM): A clinico observational study in patients of type 2 diabetes. Indian Heart J 2019;71(5):400–5.

Sample Size Calculator. URL: https://www.calculator.net/sample-size-calculator.html

Bhuyan AK, Baro A, Sarma D, Choudhury B. A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a Northeast India experience. Indian J Endocrinol Metab 2019;23(2):246–50.

Karthikeyan A, Manjunath PR, Latha AT, Sultana S. Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus. J Family Med Primary Care 2023;12(9):2070–74.

Andersen ST, Witte DR, Fleischer J, Andersen H, Lauritzen T, Jørgensen ME, et al. Risk factors for the presence and progression of cardiovascular autonomic neuropathy in type 2 diabetes: ADDITION-Denmark. Diabetes Care 2018;41(12):2586–94.

Duque A, Mediano MFF, De Lorenzo A, Rodrigues LF Jr. Cardiovascular autonomic neuropathy in diabetes: pathophysiology, clinical assessment and implications. World J Diabetes 2021;12(6):855–67.

Shalash MA, Megallaa MH, Rohoma KH, Omar MZ. Study of the prevalence of cardiovascular autonomic neuropathy in Egyptian people with type 2 diabetes mellitus. Kasr Al Ainy Med J 2018;24:136–41.

Pan Q, Li Q, Deng W, Zhao D, Qi L, Huang W, et al. Prevalence and diagnosis of diabetic cardiovascular autonomic neuropathy in Beijing, China: A retrospective multicenter clinical study. Front Neurosci 2019;13:1144.

Vasheghani M, Sarvghadi F, Beyranvand MR. The association between cardiac autonomic neuropathy and diabetes control. Diabetes, Mtab Syndr Obes 2019;12:581–7.

Downloads

Published

30-06-2024

How to Cite

1.
Ishfaq M, Saleem S, Qadir I, Amanullah, Akbar S, Humayun S. PREVALENCE OF CARDIAC AUTONOMIC NEUROPATHY AMONG TYPE 2 DIABETICS AT A TERTIARY CARE CENTRE. Pak J Phsyiol [Internet]. 2024 Jun. 30 [cited 2024 Jul. 20];20(2):11-3. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1623