PROTECTIVE EFFECT OF FLAXSEED OIL AGAINST EXEMESTANE INDUCED OSTEOPOROSIS IN ANIMAL MODEL
DOI:
https://doi.org/10.69656/pjp.v21i1.1594Keywords:
Breast cancer, osteoporosis, flaxseed oil, exemestane, estradiolAbstract
Background: Exemestane, an aromatase inhibitor is used as an adjuvant to chemotherapy for early breast cancer. The objective of this study was to see the effect of dietary flaxseed oil on bone mass density in mice model of osteoporosis induced by exemestane. Methods: This study examined three animal groups over 25 days: a Control Group on normal diet, Group A receiving exemestane (2 mg/Kg), and Group B receiving both exemestane and 10% flaxseed oil. Pre- and post-experiment weights were compared using paired t-tests. Serum oestradiol levels and femur trabecular diameter between the control and exemestane groups were compared unpaired t-tests. Chi-square test was used to analyse osteoclast cell counts between the two groups. Results: Exemestane caused statistically significant effect on weight loss (p<0.05) in Group A and B. The flaxseed group (Group B) showed a smaller increase in trabecular diameter (p<0.05) and a lesser pronounced decrease in serum oestradiol level (p<0.05) as compare to Group A. There was statistically significant difference in the number of osteoclasts between groups and Group A had more osteoclasts as compared to Group B (p<0.05). Conclusion: Combined administration of flaxseed with exemestane in mice resulted in preservation or minimal reduction of bone mass density in animal model.
Pak J Physiol 2025;21(1):29–33, DOI: https://doi.org/10.69656/pjp.v21i1.1594
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