ULTRASOUND GUIDED ASPIRATION VERSUS ASPIRATION AND ABLATION OF OVARIAN CAVITY WITH METHOTREXATE

Abstract

Background: An ovarian cyst is a fluid filled sac formed in ovaries in 20% of females during their lifetime. The objective of the study was to compare the efficacy of ultrasound guided aspiration and ultrasound guided aspiration with ablation of cavity with methotrexate in treatment of ovarian cysts. Methods: This randomized controlled trial was designed and conducted in the Department of Obstetrics and Gynaecology, Gomal Medical Teaching Hospital, Dera Ismail Khan, Pakistan  from 1^st Jun 2019 to 30^th Nov 2019. Eighty-eight women with ovarian cysts were randomly included with lottery method. The subjects were divided into 2 equal groups. The subjects in group A were subjected to ultrasound guided aspiration. The subjects in group B were subjected to ultrasound guided aspiration with ablation of cavity with methotrexate. Data was analysed on SPSS-22. Frequencies and percentages were computed for qualitative variables like efficacy. Mean±SD was presented for quantitative variables like age, size and duration of cyst. Chi-square test was applied to compare efficacy in both groups. Post stratification using Chi-square test for both groups was also applied. The results with p?0.05 were considered statistically significant. Results: Efficacy was seen in 81.8% patients in group A as compared to 97.7% in group B (p=0.01). Conclusion: Transvaginal ultrasound guided aspiration and in situ methotrexate injection is simple, non-invasive and effective in the treatment of selected cases of simple ovarian cyst without evidence of malignancy.

Pak J Physiol 2023;19(1):11-13