IRON STATUS BASED ON BLOOD TRANSFUSIONS IN PATIENTS ON HEMODIALYSIS

Abstract

Background: Multiple blood transfusions and iron therapies leads to iron overload and may lead to deposition of iron in liver. This study was carried out to determine the iron levels based on the frequency of blood transfusions in patients of chronic kidney disease on haemodialysis. Methods: In this descriptive study, total 85 chronic renal failure patients were enrolled and compared with control groups. Patients were divided into two groups on the basis of blood transfusions received. The collected blood samples were centrifuged (5,000 rpm for 10 min) and serum was assessed for Serum ferritin, Serum iron, Serum TIBC by Chemiluminescence assay. Results: The prevalence of serum iron and serum ferritin level in haemodialysis patients was significantly higher compared to control group (p=0.002 and p=0.001 respectively). On the other hand value of TIBC and transferrin saturation was significantly lower in comparison with control (p=0.006 and 0.002 respectively). Similarly there was increase in serum iron and ferritin level in haemodialysis patients who received more than 2 or multiple blood transfusions as compared to less than 2 blood transfusions. (p=0.006 and 0.001 respectively). This increase was further accompanied by decrease in TIBC and transferrin saturation in more than 2 or multiple blood transfusion patients vs less than 2 blood transfusions (p=0.007 and 0.002 respectively). No significant changes were noted in these parameters with respect to gender in case group. Conclusion: Most of the patients on haemodialysis have increased iron store in the form of ferritin.

Pak J Physiol 2019;15(1):29–31