LEVELS OF INTERLEUKIN-7 IN INTERFERON TREATED AND UNTREATED PATIENTS OF HEPATITIS-C: A CROSS-SECTIONAL STUDY

  • Alamzeb Jadoon Assistant professor, Department of Physiology, Nowshera Medical College, Nowshera (K.P), Pakistan
  • Ammar bin Saad Assistant Professor, Hematology, Department of Pathology, Ayub Medical College, Abbottabad
  • Muhammad Basharat Khan Department of Pathology, Ayub Medical College, Abbottabad
  • Muhammad Zahid Assistant Professor Physiology Nowshera Medical College Nowshera
  • Jamil Ahmed Kayani Department of Physiology, AJK Medical College, Muzaffarabad, AJK
  • Nisar Ahmed Department of Pharmacology, Ayub Medical College, Abbottabad
Keywords: Hepatitis C, Interferon, Interleukin-7, Patient, Comparison

Abstract

Background: Hepatitis C is chronic viral disease that affects liver cells. Interleukin-7 (IL-7) is an important marker in adaptive immunity as it helps immunity to fight various infections as it acts as a growth and survival factor for T lymphocytes. It improves adaptive immunity towards viral infections like hepatitis C itself. In Hepatitis C patient, its role remains debatable. In our research, we studied the levels of serum IL-7 in Control group, interferon (IFN) treated and untreated groups of Hepatitis C in order to assess the effect of IFN treatment on the indicators used. Objective of this study was to measure and compare the levels of IL-7 in treated and untreated patients of Hepatitis C. Methods: After written, informed consent, 26 subjects in each group (Control, Untreated HC patients and Interferon Treated HC patients) of both sexes were recruited from all districts of Hazara Division. The PCR was done for viral load. Serum IL-7 level was measured using ELISA. Data obtained were analysed using SPSS-20 and was compared within three groups. Results: Mean serum levels of IL-7 measured in in treated group were higher as compared to untreated groups. No statistically significant difference was observed in the serum levels of IL-7 between any of the three groups studied. Conclusions: The study showed no significant differences on comparison in IL-7 levels within control, untreated and interferon treated groups. However, with a higher number of samples may define he role of IL-7 in HC.

Pak J Physiol 2022;18(1):26‒8

References

Jafri SM, Gordon SC. Epidemiology of Hepatitis C. Clin Liver Dis (Hoboken) 2018;12(5):140–142.

Al Kanaani Z, Mahmud S, Kouyoumjian SP, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Pakistan: systematic review and meta-analyses. R Soc Open Sci 2018;5(4):180257.

Umer M, Iqbal M. Hepatitis C virus prevalence and genotype distribution in Pakistan: Comprehensive review of recent data. World J Gastroenterol 2016;22(4):1684–700.

Hézode C. Treatment of hepatitis C: Results in real life. Liver Int 2018;38(Suppl 1):21–7.

Guss D, Sherigar J, Rosen P, Mohanty SR. Diagnosis and Management of Hepatitis C Infection in Primary Care Settings. J Gen Intern Med 2018;33(4):551–7.

Gardenier D and Olson MC. Hepatitis C in 2019: Are We There Yet? J Nurs Pract 2019;15(6):415–9.

Hotchkiss RS, Steven M. Opal SM. Activating immunity to fight a foe – A New Path. N Engl J Med 2020;382:1270–2.

Zhang ZH, Jiang BC, Liu XH, Zhang MX, Li ZSN, Zhu GZ. Interleukin-7 Regulates T Follicular Helper Cell Function in Patients with Chronic Hepatitis C. Viral Immunol 2018;31(6):417–25.

Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, et al. Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial. JCI Insight 2018;3(5):e98960.

Chaturvedi N, Svarovskaia ES, Mo H, Osinusi AO, Brainard DM, Subramanian GM, McHutchison JG, Zeuzem S, Fellay J. Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes. Elife 2019 Sep 3;8:e42542.

Bolotin E, Annett G, Parkman R, Weinberg K. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant 1999;23(8):783–8.

Lundström W, Fewkes NM, Mackall CL. IL-7 in human health and disease. Semin Immunol 2012;24(3):218–24.

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Published
2022-03-31
How to Cite
1.
Jadoon A, Saad A bin, Khan M, Zahid M, Kayani JA, Ahmed N. LEVELS OF INTERLEUKIN-7 IN INTERFERON TREATED AND UNTREATED PATIENTS OF HEPATITIS-C: A CROSS-SECTIONAL STUDY. PJP [Internet]. 31Mar.2022 [cited 4Jul.2022];18(1):26-8. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1413