• Sidra Jabeen HITEC-Institute of Medical Sciences, Taxila Cantt., Pakistan
  • Humaira Fayyaz Khan Department of Physiology, Riphah International University Al-Meezan Campus, Rawalpindi, Pakistan
  • Sana Majeed Department of Physiology, Riphah International University Al-Meezan Campus, Rawalpindi, Pakistan
  • Mehvish Ashfaq Department of Physiology HITEC-Institute of Medical Sciences, Taxila Cantt., Pakistan
  • Hina Tahir Department of Physiology, AJK Medical College, Muzaffarabad, Pakistan
  • Saira Safder Department of Physiology, Islamabad Medical and Dental College, Islamabad, Pakistan.
Keywords: Vitamin D, Total Cholesterol, TG, HDL, LDL, Cholesterol ratio, Acute Coronary Syndrome


Background: Association studies have proposed a link between vitamin D levels and lipid profile. Deranged lipid profile is hallmark of acute coronary syndrome (ACS) patients. The present study was aimed to determine the role of vitamin D supplementation in improving the lipid profile of ACS patients. Methods: A total of 40 patients diagnosed with ACS were included in the study. They were divided into control (n=20) and experimental group (n=20). Experimental group received vitamin D supplementation as a single dose of 200,000 IU orally. Baseline vitamin D levels and lipid profile were done. Post sampling was done after an interval of 2 months for the same parameters. Results: The serum levels of cholesterol were decreased significantly in the experimental group (p=0.05) while TG levels showed trend towards a decrease (p=0.084). Serum HDL was increased (p=0.03), while serum LDL (p=0.04) and cholesterol ratio (p=0.012) were decreased significantly. Conclusion: Vitamin D supplementation improved lipid profile in ACS patients, and can be used as adjunct therapy in ACS patients.

Pak J Physiol 2022;18(1):32‒5


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How to Cite
Jabeen S, Khan H, Majeed S, Ashfaq M, Tahir H, Safder S. EFFECT OF VITAMIN D SUPPLEMENTATION ON LIPID PROFILE IN PATIENTS OF ACUTE CORONARY SYNDROME. PJP [Internet]. 31Mar.2022 [cited 4Jul.2022];18(1):32-5. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1406