• asad bilal arif shahida islam medical college, lodhran
  • sana younas FJMC.SGRH Lahore
Keywords: : melasma, zinc sulfate, MASI score.


Objective: To determine the mean decrease in MASI score after topical 10% zinc sulfate solution in treatment of melasma. Back ground: Melasma is a common, acquired, benign skin disorder, characterized by symmetrical hyperpigmented patches on exposed areas, predominantly the face. This study was designed to assess the efficacy of topical zinc sulphate solution (10%) in the treatment of melasma. Methods: This quasi experimental study was done at department of dermatology Sir Ganga Ram Hospital/Fatima Jinnah Medical University, Lahore, from November, 2016 to May, 2017. Seventy patients, who had epidermal type of melasma on face (assessed by woods lamp examination), of any severity and duration, were selected. All patients underwent treatment with 10% topical zinc sulfate solution twice daily for 8 weeks. The patients were advised to use sunscreen during day . The severity of melasma was assessed by MASI score at baseline and one day after completion of 8 weeks therapy. The findings were recorded on a predesigned proforma for each patient. MASI score next day after the completion of treatment was subtracted from the baseline MASI score for each patient and then mean decrease in MASI score was calculated. Results: All 70 patients completed the study. 14.3% (n=10) were male and 85.7% (n=60) were females, with mean age of 33.23+6.75 year. We recorded mean decrease in MASI score before and after treatment as 4.76+1.72 (47.36%). Conclusion: Study showed that topical 10% zinc sulfate solution is a cheap, safe and effective agent for the treatment of melasma in our population.


1. Bandyopadhyay D. topical treatment of melasma. Indian J Dermatol 2009, 54:303-9.
2. Rigopoulos D. Gregariou S, Katsambas A. Hyperpigmentation and melisma.Cosmet Dermatol 2007,6:195-202.
3. Freitag FM, Cestari TF, Leopoldo LR, Effect of melasma on quality of life in a simple of women living in southern brazil. J Eur Acad dermatol venereol 2008;22:655-62.
4. Trelles MA. Velez M. Gold MH. The treatment of melasma with topical creams alone, CO2 fractional ablative resurfacing alone, or a combination of the two. A comparative study, J Drugs Dermatol 2010; 9: 315-22.
5. HoSGY, Chan HHL. The Asian Dermatologic patient: Review of Common Pigmentary Disorders and Cutaneous Diseases. AmJ Clin Dermatol 2009;10:153-68.
6. Iraji F, Tagmirriahi N, Gavidnia K. Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma. Adv biomed Res 2012; 1:39.
7. Miot HA, Miot B, Donida L, Topical 10% zinc sulfate solution for treatment of melasma. Dermatol Surg 2009;35:2050-1.
8. Marinal Gupta, Vikram K, Mahajan, Karaninder S, Mehta and Pushpinder S Chauhan, “Zinc therapy in dermatology: A review”, Dermatology Research and Practice,vol.2014, Article ID 709152, 11 pages,2014.
9. Bagherani N, Moller BRS. An overview of zinc and its importance in dermatology-part II. The association of zinc with some dermatologic disorders. Global Dermatol 2016;3(5):337-50.
10. Sharquie KE, Al-Mashhadani SA, Salman HA. Topical 10% zinc sulfate solution for treatment of melasma, Dermatol Surg 2008;34:1346-9.
11. Achar A, Rathi SK. Melasma, a clinico-epidermiological study of 312 cases. Ind J Dermatol 2011;56(4): 380-2.
12. Ali R, Aman S, Nadeem M, Kazmi AH. Quality of life in patients of melisma. J Pak Assoc Dermatol 2013;23(2):143-8.
13. Yousefi A, Khoozani ZK, Forooshani SZ, Omrani N, Moini MA, Eskandari Y. Is topical zinc effective in the treatment of Melasma? A Double-blind Randomized comparative study. Dermatol Surg 2014;40(1): 33-7.
14. Yenny SW, Lestari W. A study comparing the use of 10% L-Ascorbic acid and 10% zinc sulfate solution in the treatment of Melasma. MJD 2012;29:38-54.


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How to Cite
arif asad, younas sana. OUTCOME OF TOPICAL 10% ZINC SULFATE SOLUTION IN THE TREATMENT OF MELASMA. PJP [Internet]. 31Mar.2019 [cited 19May2019];15(1):45-7. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/865