COMBINED EFFECT OF PIOGLITAZONE AND LEVO-CARNITINE ON SERUM LIPIDS AND ADIPONECTIN IN STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC MICE
Background: A strong relationship exists between obesity and weight gain with type 2 diabetes mellitus (T2DM) because of the ability of obesity to cause insulin resistance. The objective of this study was to determine the effect of combined supplementation of pioglitazone and levo carnitine on serum lipids and adiponectin in streptozotocin induced T2DM mice. Methods: This randomized controlled trial was carried out on 40 healthy BALB/c mice, divided into four groups. Mice were fed high fat diet for two weeks followed by intraperitoneal injection of streptozotocin. Group I served as diabetic control; group II was administered pioglitazone; group III levo carnitine and group IV was supplemented pioglitazone and levo carnitine. After six days of supplementation, the blood samples were analysed to assess insulin resistance, serum adiponectin levels and lipid profile. Results: The serum adiponectin levels revealed significant increase in combined supplemented group as compared with both diabetic control and levo carnitine groups. An improved serum lipid profile was observed in combined supplemented group as compared to the diabetic control group. There was significant positive correlation between serum adiponectin levels with high density lipoprotein (HDL-C) levels and significant negative correlation between serum adiponectin with serum total cholesterol and low density lipoprotein (LDL-C) levels in diabetic control group. Conclusions: The combined supplementation of pioglitazone and levo carnitine increases serum adiponectin levels and ameliorates dyslipidemia better than individual administration of each supplement in type 2 diabetic mice.
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