• Maryam Rao Department of Physiology, Akhtar Saeed Medical and Dental College
  • Shumaela Kanwal Department of Physiology, Akhtar Saeed Medical and Dental College
  • Qanita Mahmud University College of Medicine and Dentistry
  • Hamid J Qureshi Department of Physiology, Akhtar Saeed Medical and Dental College
  • Sibgha Zulfiqar Sheikh-Zayed Postgraduate Medical Institute, Lahore, Pakistan
Keywords: Biomarker, intrauterine fetal demise, missed abortion, Angiopoietin-1


Background: Waiting in cue for vaginal ultrasound is a stressful situation faced by patients with missed abortion. In Pakistan, it is not a usual practice to go for screening of Angiopoietin-1 for confirmation of missed abortion. This study was conducted to assess the serum Angiopoietin-1 levels in patients with missed abortion. Methods: A total of 60 women aged 20–40 years were investigated after written informed consent on the basis of convenience sampling. Out of 60, 30 women having normal viable intrauterine pregnancy with the gestational age of 6–8 weeks were enrolled as control group, and the study group included other 30 women who presented to the hospital with missed abortion at same gestational age. Results: The serum Angiopoietin-1 levels were decreased significantly in women with missed abortion compared to women having normal viable intrauterine pregnancy (780.50±134.30 vs 1102.50±112.40, p=0.001). Conclusion: The level of serum Angiopoietin-1 in missed abortion decreases and it can be used as an early and effective biomarker for diagnosis of missed abortion.

Pak J Physiol 2018:14(2):15–7


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Rao M, Kanwal S, Mahmud Q, Qureshi H, Zulfiqar S. SERUM ANGIOPOIETIN-1 AS A BIOMARKER OF MISSED ABORTION. PJP [Internet]. 30Jun.2018 [cited 4Dec.2020];14(2):15-7. Available from: