SERUM ANGIOPOIETIN-1 AS A BIOMARKER OF MISSED ABORTION

Authors

  • Maryam Rao Department of Physiology, Akhtar Saeed Medical and Dental College
  • Shumaela Kanwal Department of Physiology, Akhtar Saeed Medical and Dental College
  • Qanita Mahmud University College of Medicine and Dentistry
  • Hamid J Qureshi Department of Physiology, Akhtar Saeed Medical and Dental College
  • Sibgha Zulfiqar Sheikh-Zayed Postgraduate Medical Institute, Lahore, Pakistan

Keywords:

Biomarker, intrauterine fetal demise, missed abortion, Angiopoietin-1

Abstract

Background: Waiting in cue for vaginal ultrasound is a stressful situation faced by patients with missed abortion. In Pakistan, it is not a usual practice to go for screening of Angiopoietin-1 for confirmation of missed abortion. This study was conducted to assess the serum Angiopoietin-1 levels in patients with missed abortion. Methods: A total of 60 women aged 20–40 years were investigated after written informed consent on the basis of convenience sampling. Out of 60, 30 women having normal viable intrauterine pregnancy with the gestational age of 6–8 weeks were enrolled as control group, and the study group included other 30 women who presented to the hospital with missed abortion at same gestational age. Results: The serum Angiopoietin-1 levels were decreased significantly in women with missed abortion compared to women having normal viable intrauterine pregnancy (780.50±134.30 vs 1102.50±112.40, p=0.001). Conclusion: The level of serum Angiopoietin-1 in missed abortion decreases and it can be used as an early and effective biomarker for diagnosis of missed abortion.

Pak J Physiol 2018:14(2):15–7

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References

1. Griebel CP, Halvorsen J, Golemon TB, Day AA. Management of spontaneous abortion. Am Fam Physician 2005;72:1243–50.
2. Jibril UN, Kayode OS, Umar A, Umar AG, Abubakar IA, Ayoade IM, et al. Spontaneous abortion among women admitted into gynaecology wards of three selected hospitals in Maiduguri, Nigeria. Int J Nurs Midwifery 2014;6(2):24–31.
3. Ashaar N, Husseiny A. Correlation between missed abortion and insertional translocation involving chromosomes 1 and 7. Irian J Reprod Med 2012;10(1):15–22.
4. Phillip T, Phillip K, Reiner A Beer F, Kalousek DK. Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 2003;18:1724–32.
5. Chan YY, Jayaprakasan K, Tan A, Thornton JG, Coomarasamy A, Raine-Fenning NJ. Reproductive outcomes in women with congenital uterine anomalies: a systematic review. Ultrasound Obstet Gynecol 2011;38:371–82.
6. Nagrato C, Mattar R, Gomes MB. Adverse pregnancy outcomes in women with diabetese. Diabetol Metab Syndr 2012;4(1):41.
7. Jurkovic D, Overton C, Bender-Atik R. Diagnosis and management of first trimester miscarriage. BMJ 2013;346:f3676.
8. Allison J, Sherwood R, Schust DJ. Management of first trimester pregnancy loss can be safely moved into the office. Rev Obstet Gynecol 2011;4(1):5–14.
9. Gebreselassie H, Gallo MF, Monyo A, Johnson BR. The magnitude of abortion complications in Kenya. BJOG 2005;112:1229–35.
10. Grimes DA, Benson J, Singh S, Romero M, Ganatra B, Okonofua FE, et al. Unsafe abortion: the preventable pandemic. Lancet 2006;368(9550):1908–19.
11. Jabeen A, Dawood N, Riaz S, Tanveer S. Methods and complications of septic induced abortion in patients managed at tertiary care hospital. J Ayub Med Coll Abbottabad 2013;25(1-2):12–5.
12. Elson J, Tailor A, Salim R, Hillaby K, Dew T, Jurkovic D. Expectant management of miscarriage —prediction of outcome using ultrasound and novel biochemical markers. Hum Reprod 2005;20:2330–3.
13. Korevaar TI, Steegers EA, de Rijke YB, Schalekamp-Timmermans S, Visser WE, Hofman A, et al. Reference ranges and determinants of total hCG levels during pregnancy:the Generation R Study. Eur J Epidemiol 2015;30:1057–66.
14. Baoxia C. Angiopoietin-1, Angiopoietin-2 and myocardial ischemia reperfusion injury. J Hypertens 2012;1:e107.
15. Geva E, Glinzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB. Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor A, angiopoietin-1 and angiopoietin-2. J Clin Endocrinol Metab 2002;87:4213–24.
16. Saharinen P, Alitalo K. The yin, the yang and the angiopoietin-1. J Clin Invest 2011;121:2157–9.
17. Lee SW, Kim WJ, Jun H, Choi YK, Kim KW. Angiopoietin-1 reduces vascular endothelial growth factor induced brain endothelial permeability via upregulation of ZO-2. Int J Mol Med 2009;23:279–84.
18. Schult OW, Feinendegen LE, Zaum S, Shreeve WW, Pierson RN. Application of BMI or BSI: Differences and revisions according to age and height. J Obes 2010;(2010):647163.
19. Daponate A, Deligeoroglou E, Pournaras S, Tsezou A, Garas A, Anastasiadou F, et al. Angiopoietin-1 and angiopoietin-2 as serum biomarker for ectopic pregnancy and missed abortion. Clin Chim Acta 2013;415:145–51.
20. Schneuer FJ, Roberts CL, Ashton AW, Guilbert C, Tasevski V, Morris JM, et al. Angiopoietin-1 and 2 serum concentrations in first trimester of pregnancy Am J Obstes Gynecol 2014;210(4):345.e1–e9.
21. Kim I, Kim HG, Moon SO, Chae SW, So JN, Koh KN, et al. Angiopoietin-1 inducesendothelial cells sprouting through the activation of focal adhesion kinaseand plasmin secretion. Circ Res 2000;86:952–9.
22. Sugino N, Suzuki T, Sakata A, Miwa I, Asada H, Taketani T, et al. Angiogenesis in the human corpus luteum: changes in expression of angiopoietins in the corpus luteum throughout the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab 2005;90:6141–8.

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Published

30-06-2018

How to Cite

1.
Rao M, Kanwal S, Mahmud Q, Qureshi HJ, Zulfiqar S. SERUM ANGIOPOIETIN-1 AS A BIOMARKER OF MISSED ABORTION. Pak J Phsyiol [Internet]. 2018 Jun. 30 [cited 2024 Mar. 29];14(2):15-7. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/230