SERUM ANGIOPOIETIN-1 AS A BIOMARKER OF MISSED ABORTION
Background: Waiting in cue for vaginal ultrasound is a stressful situation faced by patients with missed abortion. In Pakistan, it is not a usual practice to go for screening of Angiopoietin-1 for confirmation of missed abortion. This study was conducted to assess the serum Angiopoietin-1 levels in patients with missed abortion. Methods: A total of 60 women aged 20â€“40 years were investigated after written informed consent on the basis of convenience sampling. Out of 60, 30 women having normal viable intrauterine pregnancy with the gestational age of 6â€“8 weeks were enrolled as control group, and the study group included other 30 women who presented to the hospital with missed abortion at same gestational age. Results: The serum Angiopoietin-1 levels were decreased significantly in women with missed abortion compared to women having normal viable intrauterine pregnancy (780.50Â±134.30 vs 1102.50Â±112.40, p=0.001). Conclusion: The level of serum Angiopoietin-1 in missed abortion decreases and it can be used as an early and effective biomarker for diagnosis of missed abortion.
Pak J Physiol 2018:14(2):15â€“7
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