ASSOCIATION OF CORD HEPCIDIN AND IRON PARAMETERS WITH MATERNAL HEPCIDIN, IRON STATUS MARKERS AND NEONATAL MORPHOMETRICS
Background: Hepcidin is the only iron regulating hormone in human body. The foetus begins to synthesize Hepcidin from the 1st trimester of gestation to control unidirectional iron transfer from mother to foetus. The objective of the present study was to determine the correlation of cord Hepcidin with iron status markers of mothers, neonates and neonatal morphometrics. Method: Twenty-five healthy pregnant women and their neonates were included in the study. Haemoglobin, Iron status markers and Hepcidin were analyzed in maternal and cord blood. Neonatal anthropometric variables were measured. Pearson/Spearman correlation was used for association of different variables of mother-neonate pairs. Results: Maternal Hepcidin showed positive correlation with maternal Iron, Ferritin and Transferrin Saturation (TS) (r=0.455 and p=0.022, r=0.511 and p=0.009, r=0.440 and p=0.025 respectively). Cord Hepcidin was positively correlated with cord iron, Ferritin and Transferrin saturation (r=0.593 and p=0.002, r=0.792 and p=0.000, r=0.546 and p=0.005 respectively). Neonatal morphometric variables were neither correlated to cord Hepcidin nor with any other Cord blood variable. Maternal Ferritin showed positive correlation with cord Haemoglobin (r=0.456, p=0.022) and cord Ferritin (r=0.460, p=0.021). Conclusion: There was no correlation between cord Hepcidin and neonatal morphometrics. Maternal and neonatal Hepcidin are independent of each other in iron status regulation.
Pak J Physiol 2018;14(2):7â€“10
2. Hintze KJ, McClung JP. Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia. Adv Hematol [Internet] 2011. ID 510304, 7 pages. Doi:10.1155/2011/510304..
3. Kwapis J, Slomka A, Zekanowska E. Hepcidin and its Role in Iron Homeostasis. EJFICC 2009;20(2):124â€“8.
4. van Santen S, Kroot JJ, Zijderveld G, Wiegerinck ET, Spaanderman ME, Swinkels DW. The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study. Clin Chem Lab Med 2013;51:1395â€“401.
5. Koenig MD, Tussing-Humphreys L, Day J, Cadwell B, Nemeth E. Hepcidin and Iron Homeostasis during Pregnancy. Nutrients. 2014; 6: 3062â€“83. Doi: 10.3390/nu60 83062.
6. Paiva Ade A, RondÃ³ PHC, Pagliusi RA, Latorre MRDO, Cardoso MAA, Gondim SSR. Relationship between the iron status of pregnant women and their newborns. Rev Saude Publica 2007;41(3):321â€“7.
7. Evans P, Cindrova-Davies T, Muttukrishna S, Burton GJ, Porter J, Jauniaux E. Hepcidin and iron species distribution inside the first-trimester human gestational sac. Mol Hum Reprod 2011;17:227â€“32.
8. Rehu M, Punnonen K, Ostland V, Heinonen S, Westerman M, Pulkki K, et al. Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol 2010;85:345â€“52.
9. Mupfudze TG, Stoltzfus RJ, Rukobo S, Moulton LH, Humphre JH, Prendergast AJ, et al. Plasma Concentrations of Hepcidin in Anemic Zimbabwean Infants. PLoS One 2015;10(8):e0135227.
10. Lee S, Guillet R, Cooper EM, Westerman M, Orlando M, Pressman E, et al. Maternal inflammation at delivery affects assessment of maternal iron status. J Nutr 2014;144:1524â€“32.
11. Villar J, Cheikh Ismail L, Victora CG, Ohuma EO, Bertino E, Altman DG, et al. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet 2014;384:857â€“68.
12. CheÅ‚chowska M, Ambroszkiewicz J, Gajewska J, JabÅ‚oÅ„ska-GÅ‚Ä…b E, Maciejewski TM, OÅ‚tarzewski M. Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length. Biol Trace Elem Res 2016;173:14â€“20.
13. Kulik-Rechberger B, Kosciesza A, Szponar E, Domosud J. Hepcidin and iron status in pregnant women and full-term newborns in first days of life. Ginekol Pol 2016;87:288â€“92.
14. Lee S, Guillet R, Cooper EM, Westerman M, Orlando M, Kent T, et al. Prevalence of anemia and associations between neonatal iron status, hepcidin and maternal iron status among neonates born to pregnant adolescents. Pediatr Res 2016;79(1-1):42â€“8.
15. Dao MC, Sen S, Iyer C, Klebenov D, Meydani SN. Obesity during pregnancy and fetal iron status: Is hepcidin the link? J Perinatol 2013;33(3):177â€“81.
16. Young MF, Griffin I, Pressman E, McIntyre AW, Cooper E, McNanley T, et al. Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources. J Nutr 2012;142:33â€“9.
17. Basu S, Kumar N, Srivastava R, Kumar A. Maternal and cord blood hepcidin concentrations in severe iron deficiency anemia. Pediatr Neonatol 2016;57:413â€“9.
18. Simavli S, Derbent AU, Uysal S, Turhan NO. Hepcidin, iron status, and inflammation variables among healthy pregnant women in the Turkish population. J Matern Fetal Neonatal Med 2014;27(1):75â€“9.
19. Albendary E, AL-Shehaa M. A comparative study between serum hepcidin level, iron status and iron deficiency anemia among recently diagnosed gestational diabetes mellitus in Qassim Area KSA. Tanta Med Sci J 2011;6(3):107â€“16.
20. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood 2008;112:4292â€“7.
21. Lorenzo L, Peter A, Poets CF, Franz AR. A review of cord blood concentrations of iron status parameters to define reference ranges for preterm infants. Neonatology 2013;104:194â€“202.
22. Kumar A, Rai AK, Basu S, Dash D, Singh JS. Cord blood and breast milk iron status in maternal anemia. Pediatrics 2008;121(3):e673â€“77.
23. Shao J, Lou J, Rao R, Georgieff MK, Kaciroti N, Felt BT, et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr 2012;142:2004â€“9.
24. Hay G, Refsum H, Whitelaw A, Melbye EL, Haug E, Borch-Iohnsen B. Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 years of life. Am J Clin Nutr 2007;86:64â€“73.
25. WHO Multicentre Growth Reference Study Group. Enrolment and baseline characteristics in the WHO Multicentre Growth Reference Study. Acta Paediatr Suppl 2006;450:7â€“15
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