Evaluation of treatment outcomes and adverse effects of drug resistant tuberculosis patients at Larkana and Sukkur tuberculosis centres

  • Ayaz Ali Unar Shaheed Mohtarma Benazir Bhutto medical university Larkana sindh pakistan
  • Abdullah Dayo Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
  • Muhammad Ali Ghoto Department of Pharmacy Practice, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
  • Khalida Unar Shah Abdul Latif University Khairpur, Sindh, Pakistan
  • Muhammad Ali Khokhar Department of Pharmacology, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
Keywords: Drug resistant tuberculosis, MDR-TB, Adverse reaction, Outcome, WHO, NTP, PMDT, Sukkar, Larkana, Pakistan

Abstract

Background: Anti-tuberculosis drug resistant is a major public health problem worldwide. It arises due to improper use of anti-tuberculous drugs in susceptible TB patients. The objectives of this study were to evaluate treatment outcomes and adverse effects of drug resistant tuberculosis patients. Methods: A descriptive cross-sectional study was conducted in two Programmatic Management of Drug Resistant Tuberculosis (PMDT) sites of Sukkur and Larkana. The sociodemographic data was obtained by a set of questionnaire following WHO guidelines. Adverse drug effects and treatment outcome data was gathered from their medical files. Results: Of a total 938 patients, 535 (57.1%) were male and 403 (42.9%) were female. Their mean age was 35.95±14.4 years in Sukkur and 35.46±11 years in Larkana. Married patients were 69%, illiterate were 46.3%, farmers 36.8%, lower class 60.4%, and rural were 68.8% patients. Previously treated cases were 83%. The MDR-TB cases were 82.8%. Diabetes mellitus as co-morbidity was 11.2%, and 41.3% were smokers. The adverse effects developed in 68.4% patients. Overall successful treatment outcome rate was 53.9%. Conclusion: Treatment outcome of drug resistant TB patients was quite low, and 68.4% patients developed adverse effects. Artharlgia was the most common adverse effect.

Pak J Physiol 2020;16(2):17−20

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Published
2020-06-26
How to Cite
1.
Unar A, Dayo A, Ghoto M, Unar K, Khokhar M. Evaluation of treatment outcomes and adverse effects of drug resistant tuberculosis patients at Larkana and Sukkur tuberculosis centres. PJP [Internet]. 26Jun.2020 [cited 4Dec.2020];16(2):17-0. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1149