PATTERN OF PAEDIATRIC MALIGNANCIES IN A TERTIARY CARE HOSPITAL IN NORTHERN PAKISTAN

  • Tanveer Ashraf Department of Paediatrics, CMH Lahore Medical College/National University of Medical Sciences, Pakistan
  • Tariq Ghafoor Department of Paediatric Oncology, CMH Rawalpindi, Pakistan
  • Saman Tanveer Army Medical College, Rawalpindi, Pakistan
Keywords: Children, Cancer, Pattern, Pakistan, Acute Lymphoblastic Leukaemia, ALL, Blood

Abstract

Background: Out of 200,000 new cases of childhood cancer worldwide, 80% are from developing countries. This study was conducted to evaluate pattern and frequency of malignant diseases among children, in northern Pakistan. Methods: This retrospective hospital based study was carried out at Paediatric Oncology Department of Combined Military Hospital Rawalpindi from 1st January 2012 to 30th June 2017. All new patients below 15 years of age with confirmed diagnosis of malignant diseases were included. Medical records of patients were analyzed and frequencies were calculated according to diagnosis, sex and age. Results: A total of 1,087 new patients, 734 male and 353 female, were included in the study. Mean age was 5.5±3.5 years. Majority of children (47.8%) were in age group 1–5 years, followed by age group 5–10 years (31.9%). Acute Lymphoblastic Leukaemia (ALL) was the commonest malignancy seen in 38.2% of patients. Other common malignancies were Acute Myeloid Leukaemia (AML) 15.5%, Hodgkin Lymphoma 7.4%, Non-Hodgkin lymphoma 5.4%, Wilms’ tumour 6.1%, Neuroblastoma 4.6%, Rhabdomyosarcoma 3.8%, Retinoblastoma 3.5% and Brain tumours 3.5%. Among infants (<1 year age), Acute leukaemia and Wilms’ tumour were more common. Overall male to female ratio was 2:1. Almost all tumours were more prevalent in males except Ewing Sarcoma (M/F 1:1.08) and Wilms’ tumour (M/F 1:1). Conclusion: Acute Lymphoblastic Leukaemia is the commonest paediatric malignancy in our population. It is in accordance with other regional and international studies. We have relatively higher frequency of AML and lower frequency of brain tumours.

Pak J Physiol 2018;14(4):21–4

Author Biographies

Tanveer Ashraf, Department of Paediatrics, CMH Lahore Medical College/National University of Medical Sciences, Pakistan

Consultant Paediatrician,

Department of Paediatrics,

CMH Lahore Medical College, Lahore,

National University of Medical Sciences,

Islamabad, Pakistan.

Tariq Ghafoor, Department of Paediatric Oncology, CMH Rawalpindi, Pakistan

Consultant Paediatric Oncologist,

Department of Paediatric Oncology,

CMH Rawalpindi, Pakistan

Saman Tanveer, Army Medical College, Rawalpindi, Pakistan

Medical student,

Army Medical College,

Rawalpindi, Pakistan.

Downloads

Download data is not yet available.
Published
2018-12-31
How to Cite
1.
Ashraf T, Ghafoor T, Tanveer S. PATTERN OF PAEDIATRIC MALIGNANCIES IN A TERTIARY CARE HOSPITAL IN NORTHERN PAKISTAN. PJP [Internet]. 31Dec.2018 [cited 19May2019];14(4):21-4. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1020