RISK ESTIMATION OF T WAVE ALTERNANS AND VENTRICULAR LATE POTENTIALS IN PATIENTS WITH CARDIOMYOPATHY

  • Hira Ashraf Department of Physiology, Foundation University Medical College, Islamabad, Pakistan
  • Madiha Imran Department of Physiology, Foundation University Medical College, Islamabad, Pakistan
  • Komal Saad Department of Physiology, Foundation University Medical College, Islamabad, Pakistan
  • Azmat Hayat Armed Forces Institute of Cardiology, Rawalpindi, Pakistan
  • Muhammad Alamgir Khan Department of Physiology, Army Medical College, Rawalpindi, Pakistan
Keywords: T wave alternans, Ventricular late potentials, Cardiomyopathy

Abstract

Background: T wave alternans and ventricular late potentials represent repolarization heterogeneity and slowing of cardiac impulse which may lead to ventricular arrhythmias. Cardiomyopathy is a disorder which puts the patients on the risk of sudden arrhythmic death. Present study was designed to evaluate the risk of developing T wave alternans and ventricular late potentials in patients with cardiomyopathy. Methods: This cross-sectional comparative study was carried out at Armed Forces Institute of Cardiology, Rawalpindi from Feb to Aug 2016. Sixty cardiomyopathic patients and 60 healthy controls were recruited through convenience sampling. Ambulatory ECG was recorded by using DMS 300-4L Holters. T wave analysis was done by Cardioscan Premier 12 Lux software. Mortara ELI 350 Electrocardiograph was used to obtain Signal Averaged ECG for analysis of Ventricular Late Potentials. Results: T wave alternans was positive in 13 (21.66%) cardiomyopathic patients while in healthy controls only 4 (6.66%) participants demonstrated positive T wave alternans. Ventricular late potentials were present in 14 (23.33%) cases and 5 (8.33%) healthy controls. The relative risk of having positive T wave alternans and ventricular late potentials was 3.3 and 2.8 times greater respectively in patients with cardiomyopathies as compared to healthy controls. Conclusion: Patients with cardiomyopathy are at higher risk of developing positive T wave alternans and ventricular late potentials. Patients positive for both parameters constitute a high-risk subset for developing ventricular arrhythmias.

Pak J Physiol 2018;14(4):14–7

Author Biographies

Hira Ashraf, Department of Physiology, Foundation University Medical College, Islamabad, Pakistan

Department of Physiology,

Foundation University Medical College,

Islamabad, Pakistan

Madiha Imran, Department of Physiology, Foundation University Medical College, Islamabad, Pakistan

Department of Physiology,

Foundation University Medical College,

Islamabad, Pakistan

Komal Saad, Department of Physiology, Foundation University Medical College, Islamabad, Pakistan

Department of Physiology,

Foundation University Medical College,

Islamabad, Pakistan

Azmat Hayat, Armed Forces Institute of Cardiology, Rawalpindi, Pakistan

Armed Forces Institute of Cardiology,

Rawalpindi, Pakistan

Muhammad Alamgir Khan, Department of Physiology, Army Medical College, Rawalpindi, Pakistan

Department of Physiology,

Army Medical College,

Rawalpindi, Pakistan

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Published
2018-12-31
How to Cite
1.
Ashraf H, Imran M, Saad K, Hayat A, Khan M. RISK ESTIMATION OF T WAVE ALTERNANS AND VENTRICULAR LATE POTENTIALS IN PATIENTS WITH CARDIOMYOPATHY. PJP [Internet]. 31Dec.2018 [cited 24Jan.2019];14(4):14-7. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1019