CLOPIDOGREL RESISTANCE AND ITS RELATION WITH AGE AND GENDER

  • Usman Nawaz Army Medical College
  • Mudassar Noor Army Medical College
  • Imran Fazal Army Medical College
  • Akbar Waheed Army Medical College
  • Saleem Ahmad Khan Army Medical College
Keywords: clopidogrel resistance, pakistan, clopidogrel responders, light transmission aggregometry, ADP

Abstract

Introduction/Objective:  Clopidogrel is an antiplatelet drug used for ischemic heart disease patients, but it is not equally effective in all the patients due to clopidogrel resistance. Clopidogrel resistance is a precursor to secondary adverse cardiac events. This study was conducted to assess the magnitude of clopidogrel resistance in Pakistan and to find its association with age and genderMethodology: This was a cross sectional study conducted from 2015-2017 at Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan. We included 390 ischemic heart disease patients, who were taking clopidogrel 75 mg/day for at least 7 days. Blood samples of all these patients were taken and platelet aggregation studies were performed with the help of light transmission aggregometer using adenosine diphosphate as an agonist. Results: Our study demonstrates that 75.1% of the patients were clopidogrel responders while 24.9% patients were clopidogrel resistant. Mean platelet aggregation of clopidogrel resistant patients was significantly higher than clopidogrel responders (60.22 ± 7.33% vs 27.73 ± 12.17%), p<0.001. There was no effect of age and gender on clopidogrel response status with p=0.266 and p=0.860 respectively. There was no difference in mean platelet aggregation of both genders (p=0.532) and among different age groups (p=0.234). Conclusion: Clopidogrel resistance is quite common in Pakistan affecting as much as quarter of local population and it is not specific to any age group or gender. 

Pak J Physiol 2019;15(1):25-8

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Published
2019-03-31
How to Cite
1.
Nawaz U, Noor M, Fazal I, Waheed A, Khan S. CLOPIDOGREL RESISTANCE AND ITS RELATION WITH AGE AND GENDER. PJP [Internet]. 31Mar.2019 [cited 16Jul.2019];15(1):25-8. Available from: http://pjp.pps.org.pk/index.php/PJP/article/view/1006