EFFECT OF SUB-CLINICAL HYPOTHYROIDISM ON CHOLESTEROL AND TRIGLYCERIDES

Authors

  • Rana Khurram Aftab Assistant Professor of Physiology, KEMU, Lahore
  • Syed Muhammad Zubair Assistant Professor of Physiology, KEMU, Lahore
  • Farhat Ijaz Assistant Professor of Physiology, CMH LMC, Lahore
  • Rana Rakhshan Aftab Student 4th Year MBBS, Rashid Latif Medical College Lahore, Pakistan

Keywords:

Sub clinical Hypothyroidism, SCH, Thyroid Stimulating Hormone, Lipid profile, Thyroxin, Triiodothyronine

Abstract

Background: Sub-clinical Hypothyroidism (SCH) is associated with dyslipidemias which may increase the cardiovascular risk. The objective of this study was to compare the serum levels of cholesterol and triglycerides in subclinical hypothyroidism and normal euthyroid subjects. Methods: This cross-sectional comparative study had control group of 50 euthyroid subjects selected from Mayo Hospital, Lahore who were advised to get thyroid profile checked. Fifty sub-clinical hypothyroid patients were included on the basis of their thyroid profile reports. Fasting blood samples were taken from both the groups for analysis of serum levels of T4, total cholesterol and Triglycerides. Student’s t-test was used to compare the mean values, and p≤0.05 was considered statistically significant. Results: Mean Triglyceride level in SCH was 168.28 mg/dl, and in euthyroid controls it was 133.62 mg/dL (p<0.001). There were no differences of total cholesterol in both groups with value of 190 mg/dL in SCH group and 189.12 in control group (p=0.912). Triglycerides level was raised in SCH and there was no pronounced effect on total cholesterol. Conclusion: The effects of SCH are more pronounced on triglycerides and less on total cholesterol.

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Pak J Physiol 2018;14(3)

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Published

20-08-2018

How to Cite

1.
Aftab RK, Zubair SM, Ijaz F, Aftab RR. EFFECT OF SUB-CLINICAL HYPOTHYROIDISM ON CHOLESTEROL AND TRIGLYCERIDES. Pak J Phsyiol [Internet]. 2018 Aug. 20 [cited 2024 Apr. 27];14(3):17-20. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/81

Issue

Vol. 14 No. 3 (2018): Pakistan Journal of Physiology

Section

Original Article

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Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, cited and quoted with full reference of, and acknowledgement to the PJP.