ROLE OF CTLA-4 IN XENOTRANPLANTATION

Authors

  • Faris Q Alenzi Department of Clinical Laboratory Science, College of Applied Medical Science, Al-Kharj University, Al-Kharj, Saudi Arabia
  • Mohammed W Al-Rabia Department of Hematology & Immunology, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
  • Badi Q Alenazi Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  • Abdulla M Mubaraki Department of Medicine, Oncology/Hematology section, Armed Forces Military Hospital, Al-Kharaj, Saudi Arabia
  • Mahmoud Lotfy Department of Molecular and Cellular, Biotechnology Research Institute, Minufiya University, Egypt
  • Mohamed Labib Salem Departments of Surgery, Medical University of South Carolina, Charleston, SC, USA
  • Haris M Siddiqui Department of Biotechnology, Integral University, Lucknow, 226026, India
  • Jamal M Arif Department of Biotechnology, Integral University, Lucknow, 226026, India
  • Shamweel Ahmad Department of Clinical Laboratory Science, College of Applied Medical Science, Al-Kharj University, Al-Kharj, Saudi Arabia
  • Ali A Al-Jabri Department of Microbiology & Immunology; College of Medicine & Health Sciences, Sultan Qaboos University, Oman
  • Richard K Wyse Department of Surgery, Hammersmith Campus, Imperial College of Medicine, DuCane Road, London, W12 0NN, UK

Abstract

The replacement of diseased organs by transplantation is now an important medical therapy. However, transplantation is limited by organ shortage. One solution to this problem is xenotransplantation, in other words, the use of organs from animal donors. Although the problem of hyperacute rejection is now largely solved, there is evidence that xenografts suffer other forms of rejection, one of them being T cell response. Moreover, evidence suggests that the degree of immunosuppression required to prevent T cell mediated xenograft rejection will be higher than that needed to prevent T cell mediated allograft rejection. Thus, strategies for graft-specific immunosuppression and improved tolerance are needed, and are discussed in this review

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Published

31-12-2009

How to Cite

1.
Alenzi FQ, Al-Rabia MW, Alenazi BQ, Mubaraki AM, Lotfy M, Salem ML, et al. ROLE OF CTLA-4 IN XENOTRANPLANTATION. Pak J Phsyiol [Internet]. 2009 Dec. 31 [cited 2024 Feb. 27];5(2):40-5. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/734