HYPERLIPIDEMIAS, DIABETES AND DEPRESSION

Authors

  • Saara Ahmad Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.
  • Rehana Rehman Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
  • Saida Haider Department of Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan
  • Zehra Batool Department of Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan
  • Fatima Ahmed Department of Ophthalmology, Liaquat National Hospital and Medical College, Karachi, Pakistan
  • Saad Bilal Ahmed Department of Geriatrics, Monash University, Melbourne, Australia

DOI:

https://doi.org/10.69656/pjp.v13i3.71

Keywords:

Diabetes mellitus, hyperlipidemias, depression, serotonin, tryptophan

Abstract

Background: Factors causing increased cholesterol levels in the body may include inactivity, obesity, genetic factors and an unhealthy diet. The high colesterol levels or hyperlipidemias may contribute to high concentrations of its precursor triglycerides and low density lipoproteins in plasma of the individuals. High triglyceride levels signal insulin resistance. This study was designed to determine an association of hyperlipidemia and diabetes mellitus with depression. Method: This case-control study involved 30 patients diagnosed with type 2 Diabetes Mellitus (DM) and hyperlipidemia (HL), and 30 non-diabetic healthy individuals having normal glucose tolerance test and no other co-morbidity. All subjects were of 30–50 years age. Blood samples from all participants were collected for determination of the HbA1C and lipid profiles. PQ9 score questionnaire for depression was asked from all subjects. Results: Patients suffering with hyperlipidemias and diabetes mellitus had higher incidence of depression compared to healthy subjects (p<0.05). Conclusion: Depression was more prevalent in hyperlipidemic and diabetic patients.

Pak J Physiol 2017;13(3):8–11

Downloads

Download data is not yet available.

Author Biography

Saara Ahmad, Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.

Dr. Saara Ahmad,

Department of Biological and Biomedical Sciences,

The Aga Khan University, Karachi, Pakistan.

Cell: +92-334-3448258

Email: saara_ahmad@hotmail.com

References

1. Fondjo LA, Owiredu WKBA, Sakyi SA, Laing EF, Adotey-Kwofie MA, Antoh EO, et al. Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana. PLoS One 2017;12(4):e0175388.
2. Allaire J, Vors C, Couture P, Lamarche B. LDL particle number and size and cardiovascular risk: anything new under the sun? Curr Opin Lipidol 2017;28(3):261–6.
3. Li CF, Chen XQ, Chen SM, Chen XM, Geng D, Liu Q, et al. Evaluation of the toxicological properties and anti-inflammatory mechanism of Hemerocallis citrina in LPS-induced depressive-like mice. Biomed Pharmacother 2017;91:167–73.
4. Wang Y, Zhang H. Serum 25-hydroxyvitamin D3 levels are associated with carotid intima-media thickness and carotid atherosclerotic plaque in type 2 diabetic patients. J Diabetes Res 2017;2017:3510275. doi: 10.1155/2017/3510275. Epub 28 Mar 2017.
5. Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, et al. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia 2017; doi: 10.1007/s00125-017-4282-7.
6. Hashemi Madani N, Ismail-Beigi F, Khamseh ME, Malek M, Ebrahimi Valojerdi A. Predictive and explanatory factors of cardiovascular disease in people with adequately controlled type 2 diabetes. Eur J Prev Cardiol 2017;24:1181–9.
7. Leveille P, Rouxel C, Plourde M. Diabetic pregnancy, maternal and fetal docosahexaenoic acid: a review of existing evidence. J Matern Fetal Neonatal Med 2017;1–6. doi: 10.1080/14767058.2017.1314460.
8. Pyatak EA, Carandang K, Vigen C, Blanchard J, Sequeira PA, Wood JR, et al. Resilient, empowered, active living with diabetes (REAL diabetes) study: methodology and baseline characteristics of a randomized controlled trial evaluating an occupation-based diabetes management intervention for young adults. Contemp Clin Trials 2017;54:8–17.
9. Gomez-Serrano M, Camafeita E, Lopez JA, Rubio MA, Breton I, García-Consuegra I, et al. Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated aging and diabetes. Redox Biol 2016;11:415–28.
10. Herder C, Fürstos JF, Nowotny B, Begun A, Strassburger K, Müssig K, et al. Associations between inflammation-related biomarkers and depressive symptoms in individuals with recently diagnosed type 1 and type 2 diabetes. Brain Behav Immun 2016;61:137–45.
11. Hellerstein DJ, Hunnicutt-Ferguson K, Stewart JW, McGrath PJ, Keller S, Peterson BS, et al. Do social functioning and symptoms improve with continuation antidepressant treatment of persistent depressive disorder? An observational study. J Affect Disord 2016;210:258–64.
12. Singh T, Goel RK. Managing epilepsy-associated depression: Serotonin enhancers or serotonin producers? Epilepsy Behav 2016;66:93–9.
13. Ancelin ML, Scali J, Norton J, Ritchie K, Dupuy AM, Chaudieu I, et al. Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression. Psychoneuroendocrinology 2016;77:90–4.
14. Quilty LC, Marshe V, Lobo DS, Harkness KL, Müller DJ, Bagby RM. Childhood Abuse History in Depression Predicts Better Response to Antidepressants with Higher Serotonin Transporter Affinity: A Pilot Investigation. Neuropsychobiology 2017;74(2):78–83.
15. Byoung-Hee L, Min-Yong K, Young-Bae P, Young-Jae P. Development of a valid and reliable seven emotions impairment questionnaire and assessment of its predictability for phlegm and blood stasis. J Tradit Chin Med 2016;36:547–54.
16. Okuyama T, Akechi T, Mackenzie L, Furukawa TA. Psychotherapy for depression among advanced, incurable cancer patients: A systematic review and meta-analysis. Cancer Treat Rev 2017;56:16–27.
17. Viazzi F, Piscitelli P, Giorda C, Ceriello A, Genovese S, Russo G, et al. AMD-Annals Study Group. Metabolic syndrome, serum uric acid and renal risk in patients with T2D. PLoS One 2017;12(4):e0176058.
18. Muenchhoff J, Song F, Poljak A, Crawford JD, Mather KA, Kochan NA, et al. Plasma apolipoproteins and physical and cognitive health in very old individuals. Neurobiol Aging 2017;55:49–60.
19. Korneva VA, Kuznetsova TY, Bogoslovskaya TY, Polyakov DS, Vasilyev VB, Orlov AV, et al. Cholesterol Levels in Genetically Determined Familial Hypercholesterolaemia in Russian Karelia. Cholesterol 2017;2017:9375818.
20. Unnikrishnan R, Anjana RM, Amutha A, Ranjani H, Jebarani S, Ali MK, et al. Younger-onset versus older-onset type 2 diabetes: Clinical profile and complications. J Diabetes Complications 2017;31(6):971–5.
21. Alghamdi AS, Yahya MA, Alshammari GM, Osman MA. Prevalence of overweight and obesity among police officers in Riyadh City and risk factors for cardiovascular disease. Lipids Health Dis 2017;16(1):79.
22. Gluchowski NL, Becuwe M, Walther TC, Farese RV Jr. Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol 2017;14:343–55.
Pak J Physiol 2017;13(3)

Downloads

Published

30-09-2017

How to Cite

1.
Ahmad S, Rehman R, Haider S, Batool Z, Ahmed F, Ahmed SB. HYPERLIPIDEMIAS, DIABETES AND DEPRESSION. Pak J Phsyiol [Internet]. 2017 Sep. 30 [cited 2024 Nov. 21];13(3):8-11. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/71

Issue

Vol. 13 No. 3 (2017): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.