REFERENCE RANGE VALUES OF HAEMATOLOGICAL PARAMETERS IN HEALTHY PAKISTANI ADULTS

Abstract

Objectives: This study has been designed and conducted to establish the normal values of various haematological parameters for healthy adult Pakistani males and females, and to compare these values with those obtained for other populations in both western and tropical countries. Methods: This study was under taken in reference adult Pakistani Populations in the area of Multan, Pakistan. A total 302 healthy volunteers whose ages ranged between 20–45 years, were investigated. All laboratory analysis was conducted under standardized conditions at the Haematology Section, Department of Pathology, Bakhtawar Amin Memorial Trust, Hospital (BAMTH) and Multan Institute of Cardiology, (MIC). Results: In Males, the mean Haemoglobin concentration (Hb) of 13.04 g/dl and Haematocrit (HCT) ratio of 0.39 l/l were significantly higher than females value of 11.63 g/dl and 0.35 l/l respectively. The mean Red Blood Cell (RBC) count of 5.3´10¹²/l in males was also significantly higher than the corresponding value of 4´10¹²/l in females (p<0.05). The value of Mean Corpuscular Volume (MCV) in males (76.30 fl) was significantly higher than in females (73.84 fl), (p<0.05). Similarly the Mean Corpuscular Haemoglobin (MCH) and Mean Corpuscular Haemoglobin Concentration (MCHC) were significantly higher in males than corresponding values in females (p<0.05). On the other hand, the mean White Blood Cell count (WBC) of 8.25´10⁹/l in males was lower than mean value of 8.42´10⁹/l in females (p<0.05). Similarly the values for Platelet count of 255´10⁹/l in males were also significantly lower than corresponding values of 255´10⁹/l in females (p<0.05). Conclusions: This study has established baseline values for haematological parameters in healthy Pakistani adults of Multan and surrounding areas. The sex difference of measured levels of all of these parameters has attained statistical significance. When the observed values of this study were compared with those quoted for the methods in use and those drawn from different populations, significant differences were revealed. Such differences are of accurate clinical interpretation of haematological investigation of patients.