COMPARISON OF KI-67/MIB-1 LABELLING INDEX AND HISTOPATHOLOGICAL GRADING OF ASTROCYTOMA

Authors

  • Abdul Rehman Qaisrani Ghazi Khan Medical College, Dera Ghazi Khan, Pakistan.
  • Rozina Jaffar Services Institute of Medical Sciences, Lahore, Pakistan.
  • Naseem Jahan Ghazi Khan Medical College, Dera Ghazi Khan, Pakistan.
  • Tehseen Iqbal Ghazi Khan Medical College, Dera Ghazi Khan, Pakistan.

DOI:

https://doi.org/10.69656/pjp.v13i2.45

Keywords:

astrocytoma, immunohistochemical grading, histopathological grading, Ki-67

Abstract

Background: Astrocytomas are common malignant brain tumours. Ki-67/MIB-1 index serves as an important supplementary tool in the diagnosis and prognosis of human astrocytoma. Methods: Forty (40) cases of various histopathological (WHO) grades of astrocytoma (Pilocytic, diffuse, Anaplastic and Glioblastoma multiforme) were included in this study. Ki-67/MIB-1 labelling index of these tumours was estimated by immunohistochemistry, performed on paraffin sections. Histopathological grading and Ki-67/MIB-1 labelling index were compared. The results were analyzed by one way ANOVA. Results: Out of 40 cases two were diagnosed as pilocytic astrocytoma (WHO grade-1) with a mean Ki-67/MIB-1 labelling index of 0.7±1.4 (range 0.6–0.8%). Thirteen cases were of diffuse astrocytoma (WHO grade II), with a mean Ki-67/MIB-1 labelling index of 3.07±3.7 (range 1–15%). Nine cases were diagnosed as Anaplastic astrocytoma (WHO grade III) with a mean Ki-67/MIB-1 labelling Index of 11.55±7.8 (range 2–35%). Sixteen cases were diagnosed as Glioblastoma multiforme with a mean Ki-67/MIB-1 labelling Index of 14.1±8.9 (range (5–36%). ANOVA showed a significant differences between four compared groups (p=0.003). Conclusion: Immunohistochemical analysis of Ki-67/MIB-1 labelling index increases significantly with increasing grade of malignancy. The Ki-67/MIB-1 labelling index can be used as an adjuvant to histopathological grading for proper diagnosis and grading of astrocytoma especially in borderline cases and in small biopsies.

Keywords: astrocytoma, immunohistochemical grading, histopathological grading, Ki-67

Pak J Physiol 2017;13(2):19–21

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Pak J Physiol 2017;13(2)

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Published

30-06-2017

How to Cite

1.
Qaisrani AR, Jaffar R, Jahan N, Iqbal T. COMPARISON OF KI-67/MIB-1 LABELLING INDEX AND HISTOPATHOLOGICAL GRADING OF ASTROCYTOMA. Pak J Phsyiol [Internet]. 2017 Jun. 30 [cited 2024 Nov. 23];13(2):19-21. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/45

Issue

Vol. 13 No. 2 (2017): Pakistan Journal of Physiology

Section

Original Article

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Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.