COMBINED EFFECT OF PIOGLITAZONE AND LEVO-CARNITINE ON SERUM LIPIDS AND ADIPONECTIN IN STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC MICE

Authors

  • Shahida Parveen
  • Muhammad Mazhar Hussain
  • mahvash khan

DOI:

https://doi.org/10.69656/pjp.v14i3.440

Keywords:

Adiponectin, Pioglitazone, Levo carnitine

Abstract

Background: A strong relationship exists between obesity and weight gain with type 2 diabetes mellitus (T2DM) because of the ability of obesity to cause insulin resistance. The objective of this study was to determine the effect of combined supplementation of pioglitazone and levo carnitine on serum lipids and adiponectin in streptozotocin induced T2DM mice. Methods: This randomized controlled trial was carried out on 40 healthy BALB/c mice, divided into four groups. Mice were fed high fat diet for two weeks followed by intraperitoneal injection of streptozotocin. Group I served as diabetic control; group II was administered pioglitazone; group III levo carnitine and group IV was supplemented pioglitazone and levo carnitine. After six days of supplementation, the blood samples were analysed to assess insulin resistance, serum adiponectin levels and lipid profile. Results: The serum adiponectin levels revealed significant increase in combined supplemented group as compared with both diabetic control and levo carnitine groups. An improved serum lipid profile was observed in combined supplemented group as compared to the diabetic control group. There was significant positive correlation between serum adiponectin levels with high density lipoprotein (HDL-C) levels and significant negative correlation between serum adiponectin with serum total cholesterol and low density lipoprotein (LDL-C) levels in diabetic control group. Conclusions: The combined supplementation of pioglitazone and levo carnitine increases serum adiponectin levels and ameliorates dyslipidemia better than individual administration of each supplement in type 2 diabetic mice.

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Pak J Physiol 2018;14(3)

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Published

20-08-2018

How to Cite

1.
Parveen S, Hussain MM, khan mahvash. COMBINED EFFECT OF PIOGLITAZONE AND LEVO-CARNITINE ON SERUM LIPIDS AND ADIPONECTIN IN STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC MICE. Pak J Phsyiol [Internet]. 2018 Aug. 20 [cited 2024 Nov. 23];14(3):7-10. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/440

Issue

Vol. 14 No. 3 (2018): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.