EFFECTS OF ANTIEPILEPTIC DRUG THERAPY ON 25OH VITAMIN D LEVELS
DOI:
https://doi.org/10.69656/pjp.v11i4.412Keywords:
Epilepsy, Anti epileptic drug therapy, osteoporosis, ricketsAbstract
Epilepsy is a chronic condition with an incidence of 4–10/1,000 worldwide, Antiepileptic drugs (AED) in common use are carbamazepine (CBZ), phenytoin (DPH), phenobarbitone (PB), and sodium valproate. The effect of AEDs on the vitamin D metabolism is of considerable value especially in children. There are few clinicians who use prophylactic calcium or vitamin D for patients taking AED. The objective of this study was to determine the effect of antiepileptic drugs on vitamin D by measuring 25OH vitamin D levels in patients on AEDs. Methods: This case control study was conducted in paediatric department, Fauji Foundation Hospital Rawalpindi. In a duration of 6 months, 34 cases of epileptic children taking CBZ and valproic acid for more than 3 months were selected and 25OH Vitamin D levels were measured and compared with 25OH Vit D levels in healthy controls. Results: Out of 34 cases, 11 (32.4%) cases had decreased vitamin D levels (≤20 ηg/dL) whereas 2 (5.9%) had decreased vitamin D levels in control group (p=0.006). Conclusion: Antiepileptic drugs negatively effect bone metabolism and increase the risk of osteoporosis, fractures and rickets in children.
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Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.