EFFECTS OF ANTIEPILEPTIC DRUG THERAPY ON 25OH VITAMIN D LEVELS

Authors

  • Maryam Rafiq PAF Hospital, E9, Islamabad, Pakistan
  • Sajida Bano Department of Biochemistry, AJK Medical College, Muzaffarabad
  • Parveen Akhtar Tariq Akhtar Tariq Department of Paediatrics, Foundation University Medical College, Islamabad

Keywords:

Epilepsy, Anti epileptic drug therapy, osteoporosis, rickets

Abstract

Epilepsy is a chronic condition with an incidence of 4–10/1,000 worldwide, Antiepileptic drugs (AED) in common use are carbamazepine (CBZ), phenytoin (DPH), phenobarbitone (PB), and sodium valproate. The effect of AEDs on the vitamin D metabolism is of considerable value especially in children. There are few clinicians who use prophylactic calcium or vitamin D for patients taking AED. The objective of this study was to determine the effect of antiepileptic drugs on vitamin D by measuring 25OH vitamin D levels in patients on AEDs. Methods: This case control study was conducted in paediatric department, Fauji Foundation Hospital Rawalpindi. In a duration of 6 months, 34 cases of epileptic children taking CBZ and valproic acid for more than 3 months were selected and 25OH Vitamin D levels were measured  and compared with 25OH Vit D levels in healthy controls. Results: Out of 34 cases, 11 (32.4%) cases had decreased vitamin D levels (≤20 ηg/dL) whereas 2 (5.9%) had decreased vitamin D levels in control group (p=0.006). Conclusion: Antiepileptic drugs negatively effect bone metabolism and increase the risk of osteoporosis, fractures and rickets in children.

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Published

31-12-2015

How to Cite

1.
Rafiq M, Bano S, Tariq PATA. EFFECTS OF ANTIEPILEPTIC DRUG THERAPY ON 25OH VITAMIN D LEVELS. Pak J Phsyiol [Internet]. 2015 Dec. 31 [cited 2024 Feb. 27];11(4):24-6. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/412