HAEMOGLOBIN STATUS IN REPRODUCTIVE AGE GROUP WOMEN USING HORMONAL CONTRACEPTIVES

Authors

  • Fauzia Aitazaz Department of Physiology, AJK Medical College, Muzaffarabad
  • Shireen Jawed University Medical and Dental College, University of Faisalabad
  • Aurangzeb Bhatti Department of Pathology, CMH, Peshawar
  • Afsheen Akbar Department of Physiology, Avicenna Medical College, Lahore, Pakistan

DOI:

https://doi.org/10.69656/pjp.v12i1.411

Keywords:

Progestin only injection, COC pills, haemoglobin, anaemia, weight gain, pill, contraceptives

Abstract

Background: Hormonal contraceptive use can be a trigger to altered levels of haemoglobin in reproductive age group women leading to anaemia. The objective of this study was to evaluate levels of haemoglobin in women of reproductive age using hormonal contraceptives. Methods: It was a case control study conducted in Family Health Hospital, Johar Town, Lahore. The study group women attending the Family Planning Unit were using low dose COC pills, Depomedroxyprogesterone acetate (DMPA) 3-monthly injection, or Norethisterone-enanthate (NET-EN) 2-monthly injections. Blood samples were obtained and haematological tests were run on the samples. Results: Tests revealed that women using injectable hormonal contraceptives were more prone to decreased haemoglobin levels after prolonged use as compared to those using COC pills. Conclusion: Long term use of progestin only injections can lead to anaemia as compared to COC pills in women of reproductive age group.

Pak J Physiol 2016;12 (1):10–2

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References

1. Pakistan Population Review, 2003.
2. Huma Naz, Bushra Begum. Prevalence and associated risk factors of anaemia in pregnant women in a teaching hospital, Korangi Industrial Area. Pak J Surg 2013;29(2):131–3.
3. Stott PC. The outcome of menorrhagia: a retrospective case control study. J Royal Coll Gen Practit 1983;33:715–20.
4. Hickey M, Krikun G, Kodaman P, Schatz F, Carati C, Lockwood CJ. Long-term progestin-only contraceptives result in reduced endometrial blood flow and oxidative stress. J Clin Endocrinol Metabol 2006;91(9):3633–3.
5. Morison NB, Zhang J, Kaitu’u-Lino TJ, Fraser IS, Salamonsen LA. The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women. Reproduction 2007;133:309–21.
6. Girling JE, Heryanto B, Patel N, Rogers PA. Effect of long-term progestin treatment on endometrial vasculature in normal cycling mice. Contraception 2004;70:343–50.
7. Sereepapong W, Chotnopparatpattara P, Taneepanichskul S, Markham R, Russell P, Fraser IS. Endometrial progesterone and estrogen receptors and bleeding disturbances in depot medroxyprogesterone acetate users. Hum Reprod 2004;19(3):547–52.
8. Charles J. Lockwood, Graciela Krikun, Martha Hickey, S. Joseph Huang, Frederick Schatz. Decidualized human endometrial stromal cells mediate hemostasis, angiogenesis, and abnormal uterine bleeding. Reprod Sci 2009;16(2):162–70.
9. Sarina Schrager. Abnormal uterine bleeding associated with hormonal contraception. Am Fam Physician 2002;65:2073–80, 2083.
10. Pakistan Bureau of Statistics. Annual Contraceptive Performance Report 2012¬–2013.
11. Espey E, Steinhart J, Ogburn T, Qualls C. Depo-provera associated with weight gain in Navajo women.Contraception 2000;62(2):55–8.
12. Beckmann CRB, Herbert W, Laube D. Injectable Hormonal Contraceptives-Side Effects. In: Obstetrics and Gynecology. 7th Ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014. p. 244.
13. Ghazala N, Saima N, Shafqut A, Sheheen A. Anaemia: The neglected female health problem in developing countries. J Ayub Med Coll Abbottabad 2011;23(2):8–11.
14. Martha Hickey, Sweta Agarwal. Unscheduled bleeding in combined oral contraceptive users: focus on extended-cycle and continuous-use regimens J Fam Plann Reprod Health Care 2009;35(4):245–8.
15. Bandhi G, Bhawnani D, Verma N, Soni GP. Assessment of contraceptive knowledge and practices among reproductive age group of women in urban slums of Raipur City, Chhattisgarh, India. Natl J Community Med 2014;5(4):349–54.
16. Coata G, Ventura F, Lombardini R, Ciuffetti G, Cosmi EV, Di Renzo GC. Effect of low-dose oral triphasic contraceptives on blood viscosity, coagulation and lipid metabolism. Contraception 1995;52(3):151–7.
17. Mooij PN, Thomas CM, Doesburg WH, Eskes TK. The effects of oral contraceptives and multivitamin supplementation on serum ferritin and hematological parameters. Int J Clin Pharmacol Ther Toxicol 1992;30(2):57–62.
18. Milman N, Kirchhoff M, Jorgensen T. Iron status markers, serum ferritin and hemoglobin in 1359 Danish women in relation to menstruation, hormonal contraception, parity, and postmenopausal hormone treatment. Ann Hematol 1992;65:96–102.
19. Bonny EA, Zeigler J, Harvey R, Dubanne MS, Secic M, Cromer AB. Weight gain in obese and nonobese adolescent girls initiating depot medroxyprogesterone, oral contraceptive pills, or no hormonal contraceptive method. Arch Pediatr Adolesc Med 2006;160(1):40–5.
20. Lopez LM, Edelman A, Chen M, Otterness C, Trussel J, Helmerhorst FM. Progestin only contraceptives: effect on weight. Cochrane Database Syst Rev 2013;7:CD008815. doi: 10.1002/14651858.CD008815

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Published

31-03-2016

How to Cite

1.
Aitazaz F, Jawed S, Bhatti A, Akbar A. HAEMOGLOBIN STATUS IN REPRODUCTIVE AGE GROUP WOMEN USING HORMONAL CONTRACEPTIVES. Pak J Phsyiol [Internet]. 2016 Mar. 31 [cited 2024 Dec. 22];12(1):10-2. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/411

Issue

Vol. 12 No. 1 (2016): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.