INTERMITTENT CLAUDICATION IN TYPE 2 DIABETES MELLITUS PATIENTS

Authors

  • Muhammad Ishaq Department of Physiology, North West School of Medicine, Peshawar
  • Ghulam Jillani Khan Khyber Medical College, Peshawar
  • Sibgha Zulfiqar Shaikh Zayed, Federal Postgraduate Medical Institute, Lahore, Pakistan

DOI:

https://doi.org/10.69656/pjp.v12i1.409

Keywords:

Intermittent Claudication, Peripheral Neuropathies, Type 2 Diabetes Mellitus, T2DM

Abstract

Background: Intermittent claudication (IC), mainly attributable to peripheral arterial disease (PAD) is the experiencing of pain in legs, especially calf muscles, during walking. Diabetic peripheral neuropathies (DPN) are the commonest sequelae of diabetes mellitus. DPN affect up to 50% of patients with type 1 and type 2 diabetes mellitus. Neuropathies usually represent as numbness, tingling, pain, and weakness etc. The purpose of this study was to see the complications in type 2 diabetics. Methods: The study was conducted at Shaikh Zayed Federal Postgraduate Medical Institute, Lahore. A total of 150 patients, (age ≥40) with type 2 diabetes mellitus, were selected from the Diabetic Clinic, Cardiology Unit, and Biochemistry Department of the Institute. The subjects were divided into uncomplicated and complicated groups. Blood pressure, Ankle Brachial Index, Body Mass Index and neurological symptoms of each patient were recorded. The ‘Edinburgh Claudication Questionnaire’ was used to assess intermittent claudication. The urine of each patient was tested for microalbuminuria to label him as complicated type 2 diabetic or otherwise. The data were analysed on SPSS-16. Results: In both groups about 8% individuals experienced generalised pain, and 3% felt numbness. Tingling sensations in the uncomplicated group were experienced by none, but 2.7% of the individuals in the complicated group complained about the ailment. No one was suffering from intermittent claudication in the uncomplicated group, but 6.7% of the individuals in the complicated group reported the problem and the differences between the groups were significant statistically (p<0.05). Conclusion: The complications in type 2 diabetics are more compared to uncomplicated type 2 diabetics.

Pak J Physiol 2016;12(1):3–5

Downloads

Download data is not yet available.

References

1. Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey 1999–2000. Circulation 2004;110:738–43.
2. Pasternak RC, Criqui MH, Benjamin EJ, Fowkes FGR, Isselbacher EM, McCullough PA, et al. Atherosclerotic Vascular Conference: Writing Group I. epidemiology. Circulation 2004;109:2605–12.
3. Akram J, Aamir AU, Basit A, Qureshi MS, Mehmood T, Shahid SK, et al. Prevalence of peripheral arterial disease in type 2 diabetics in Pakistan. J Pak Med Assoc 2011;61(7):644–8.
4. Muller MD, Reed AB, Leuenberger UA, Sinoway LI. Physiology in Medicine: Peripheral Arterial Disease. J Appl Physiol 2013;115(9):1219–26.
5. Edmundsson D, Svensson O, Toolanen G. Intermittent claudication in diabetes mellitus due to chronic exertional compartment syndrome of the leg: an observational study of 17 patients. Acta Orthop 2008;79(4):534–9.
6. Tucker AK. Chronic exertional compartment syndrome of the leg. Curr Rev Musculoskelet Med 2010;3(1–4):32–7.
7. Pasnoor M, Dimachkie MM, Kluding P, Barohn RJ. Diabetic neuropathy part 1: overview and symmetric phenotypes. Neurol Clin 2013;31(2):425–45.
8. Hartemann A, Attal N, Bouhassira D, Dumont I, Gin H, Jeanne S, et al. Painful diabetic neuropathy: diagnosis and management. Diabetes Metab 2011;37(5):377–88.
9. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, et al; American Diabetes Association. Diabetic neuropathies. Diabetes Care 2005;28(4):956–62.
10. Leng G, Fowkes F. The Edinburgh claudication questionnaire: an improved version of the WHO/ROSE questionnaire for use in epidemiological surveys. J Clin Epidemiol 1992;45:1101–9.
11. Jensen SA, Vatten LJ, Myhre HO. The association between diabetes mellitus and the prevalence of intermittent claudication: the HUNT study. Vasc Med 2008;13:239–44.
12. Harris M, Eastman R, Cowie C. Symptoms of sensory neuropathy in adults with NIDDM in the US population. Diabetes Care 1993;16(11):1446–52.
13. McBride MR, Mistretta CM. Light Touch Thresholds in diabetic patients. Diabetes Care 1982;5(3):311–5.
14. Vinik AI, Holland MT, Le Beau JM, Liuzzi FJ, Stansberry KB, Colen LB. Diabetic neuropathies. Diabetes Care 1992;15(12):1926–75.
15. Asad A, Hameed MA, Khan UA, Butt MRA, Ahmed N, Nadeem A. Comparison of nerve conduction studies with diabetic neuropathy symptom score and diabetic neuropathy examination score in type-2 diabetics for detection of sensorimotor polyneuropathy. J Pak Med Assoc 2009;59:594–8.

Downloads

Published

31-03-2016

How to Cite

1.
Ishaq M, Khan GJ, Zulfiqar S. INTERMITTENT CLAUDICATION IN TYPE 2 DIABETES MELLITUS PATIENTS. Pak J Phsyiol [Internet]. 2016 Mar. 31 [cited 2024 Nov. 21];12(1):3-5. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/409