ASSOCIATION OF HYPERTENSION WITH APOE4 AND LIPID PROFILE IN WOMEN WITH DIFFERENT MENOPAUSAL STATUS

Authors

  • Burarah Arooj Institute of Biochemistry and Biotechnology, University of Punjab, Lahore
  • Rukhshan Khurshid Department of Biochemistry, Fatima Jinnah Medical College, Lahore
  • Naheed Hashmat Department of Medicine, Sir Ganga Ram Hospital Lahore
  • Mahjabeen Saleem Institute of Biochemistry and Biotechnology, University of Punjab, Lahore

DOI:

https://doi.org/10.69656/pjp.v9i2.386

Keywords:

Lipid profile, ApoE4, ApoE2, Menstrual status

Abstract

Background: An association between ApoE4 and ApoE2 alleles with high blood pressure in relation to different menstrual phases has been observed. Objectives: To examine the association between lipid profile, ApoE polymorphism and hypertension in a group of peri- and postmenopausal women. Methods: Study included 63 hypertensive female patients having age range of 45–80 years. Patients were divided into two groups based on their menopausal status. Group A included 43 hypertensive peri- menopausal women and Group B included 21 hypertensive post-menopausal women. Thirty age-matched normal healthy subjects were taken as controls. Patients were taken from medical out-door of Sir Ganga Ram Hospital, and Services Hospital, Lahore. ApoE4 and lipid profile were measured in all subjects. Results: In peri-menopausal women E2/2 was 42% and it was 60% in postmenopausal women. E4/4 was 58% and 40% in peri- and postmenopausal women respectively. Level of serum cholesterol and the carrier lipoproteins LDL-c and VLDL-c were increased in peri-menopausal women as compared to postmenopausal women but significant difference (p<0.05) was only observed in case of LDL-cholesterol. The levels of serum triglyceride and carrier lipoprotein HDL cholesterol were decreased in peri-menopausal women compared to postmenopausal women but significant difference (p<0.05) was only observed in case of triglyceride. Conclusion: Both, peri- and postmenopausal conditions are associated with APOE genotypes and altered serum lipid profile and thus an independent risk factor for developing cardiovascular diseases especially in postmenopausal women.

Pak J Physiol 2013;9(2):29–31

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Published

31-12-2013

How to Cite

1.
Arooj B, Khurshid R, Hashmat N, Saleem M. ASSOCIATION OF HYPERTENSION WITH APOE4 AND LIPID PROFILE IN WOMEN WITH DIFFERENT MENOPAUSAL STATUS. Pak J Phsyiol [Internet]. 2013 Dec. 31 [cited 2024 Dec. 22];9(2):29-31. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/386

Issue

Vol. 9 No. 2 (2013): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.