ASSOCIATION OF HYPERTENSION WITH APOE4 AND LIPID PROFILE IN WOMEN WITH DIFFERENT MENOPAUSAL STATUS

Authors

  • Burarah Arooj Institute of Biochemistry and Biotechnology, University of Punjab, Lahore
  • Rukhshan Khurshid Department of Biochemistry, Fatima Jinnah Medical College, Lahore
  • Naheed Hashmat Department of Medicine, Sir Ganga Ram Hospital Lahore
  • Mahjabeen Saleem Institute of Biochemistry and Biotechnology, University of Punjab, Lahore

DOI:

https://doi.org/10.69656/pjp.v9i2.386

Keywords:

Lipid profile, ApoE4, ApoE2, Menstrual status

Abstract

Background: An association between ApoE4 and ApoE2 alleles with high blood pressure in relation to different menstrual phases has been observed. Objectives: To examine the association between lipid profile, ApoE polymorphism and hypertension in a group of peri- and postmenopausal women. Methods: Study included 63 hypertensive female patients having age range of 45–80 years. Patients were divided into two groups based on their menopausal status. Group A included 43 hypertensive peri- menopausal women and Group B included 21 hypertensive post-menopausal women. Thirty age-matched normal healthy subjects were taken as controls. Patients were taken from medical out-door of Sir Ganga Ram Hospital, and Services Hospital, Lahore. ApoE4 and lipid profile were measured in all subjects. Results: In peri-menopausal women E2/2 was 42% and it was 60% in postmenopausal women. E4/4 was 58% and 40% in peri- and postmenopausal women respectively. Level of serum cholesterol and the carrier lipoproteins LDL-c and VLDL-c were increased in peri-menopausal women as compared to postmenopausal women but significant difference (p<0.05) was only observed in case of LDL-cholesterol. The levels of serum triglyceride and carrier lipoprotein HDL cholesterol were decreased in peri-menopausal women compared to postmenopausal women but significant difference (p<0.05) was only observed in case of triglyceride. Conclusion: Both, peri- and postmenopausal conditions are associated with APOE genotypes and altered serum lipid profile and thus an independent risk factor for developing cardiovascular diseases especially in postmenopausal women.

Pak J Physiol 2013;9(2):29–31

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References

1. Fuzikawa AK, Peixoto SV, Taufer M, Moriguchi EH, Lima-Costa MF. Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambui Health Aging Study (BHAS). Braz J Med Biol Res 2008;41(2):89–94.
2. Zhao Q, Kelly TN, Li C, He J. Progress and future aspects in genetics of human hypertension. Curr Hypertens Rep 2013;15(6):676–86.
3. von Muhlen D, Barrett-Connor E, Kritz-Silverstein D. Apolipoprotein E genotype and response of lipid levels to postmenopausal estrogen use. Atherosclerosis 2002;161(1):209–14.
4. Volcik KA, Barkley RA, Hutchinson RG, Mosley TH, Heiss G, Sharrett AR, et al. Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants. Am J Epidemiol 2006;164(4):342–8.
5. Rastas S, Mattila K, Verkkoniemi A, Niinisto L, Juva K, Sulkava R, et al. Association of apolipoprotein E genotypes, blood pressure, blood lipids and ECG abnormalities in a general population aged 85+. BMC Geriatr 2004;4:1.
6. Stoumpos S, Hamodrakas SJ, Anthopoulos PG, Bagos PG. The association between apolipoprotein E gene polymorphisms and essential hypertension: a meta-analysis of 45 studies including 13,940 cases and 16,364 controls. J Hum Hyperten 2013;27(4):245–55.
7. Lea Correa Leite M, Lima-Costa MF, Moriguchi EH. Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambui Cohort Study of Ageing (1997–2008). Hypertens Res 2013;36(3):270–6.
8. Zende PD, Bankar MP, Kamble PS, Momin AA. Apolipoprotein e gene polymorphism and its effect on plasma lipids in arteriosclerosis. J Clin Diagn Res 2013;7(10):2149–52.
9. Schaefer EJ, Lamon-Fava S, Johnson S, Ordovas JM, Schaefer MM, Castelli WP, et al. Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. Arterioscler Thromb Vasc Biol 1994;14:1105–13.
10. Haffner SM, Newcomb PA, Marcus PM, Klein BE, Klein R. Relation of sex hormones and dehydroepiandrosterone sulfate (DHEA-SO4) to cardiovascular risk factors in postmenopausal women. Am J Epidemiol 1995;142(9):925–34.
11. Bales AC. In search of lipid balance in older women. New studies raise questions about what works best. Postgrad Med 2000;108(7):57–60,6,9–72.
12. Matthan NR, Jalbert SM, Lamon-Fava S, Dolnikowski GG, Welty FK, Barrett HR, et al. TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status. Arterioscler Thromb Vasc Biol 2005;25(8):1691–6.
13. Bonithon-Kopp C, Scarabin PY, Darne B, Malmejac A, Guize L. Menopause-related changes in lipoproteins and some other cardiovascular risk factors. Int J Epidemiol 1990;19(1):42–8.
14. Igweh JC, Nwagha IU, Okaro JM. The effects of menopause on the serum lipid profile of normal females of South East Nigeria. Niger J Physiol Sci 2005;20(1-2):48–53.
15. Reddy Kilim S, Chandala SR. A comparative study of lipid profile and oestradiol in pre- and post-menopausal women. J clin diagn Res 2013;7(8):1596–8.
16. Mahley RW, Innerarity TL, Rall SC, Jr, Weisgraber KH. Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res 1984;25(12):1277–94.
17. Syvanen AC, Sajantila A, Lukka M. Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing. Am J Hum Genet 1993;52(1):46–59.
18. Nicklas BJ, Ferrell RE, Bunyard LB, Berman DM, Dennis KE, Goldberg AP. Effects of apolipoprotein E genotype on dietary-induced changes in high-density lipoprotein cholesterol in obese postmenopausal women. Metabolism 2002;51(7):853–8.
19. Yasuno F, Tanimukai S, Sasaki M, Ikejima C, Yamashita F, Kodama C, et al. Effect of plasma lipids, hypertension and APOE genotype on cognitive decline. Neurobiol Aging 2012;33(11):2633–40.

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Published

31-12-2013

How to Cite

1.
Arooj B, Khurshid R, Hashmat N, Saleem M. ASSOCIATION OF HYPERTENSION WITH APOE4 AND LIPID PROFILE IN WOMEN WITH DIFFERENT MENOPAUSAL STATUS. Pak J Phsyiol [Internet]. 2013 Dec. 31 [cited 2024 Nov. 21];9(2):29-31. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/386

Issue

Vol. 9 No. 2 (2013): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.