THE LOCAL EFFECTS OF HONEY ON DIABETIC FOOT DISORDER
DOI:
https://doi.org/10.69656/pjp.v9i1.326Keywords:
antioxidant, antimicrobial, immune-stimulation, anti-inflammation, anti-tumour and Diabetic foot disordersAbstract
Both the Qur’an and Hadith refer to honey as a healer of many health disorders in humans. The use of honey to treat and prevent many disorders has been well documented highlighting antioxidant, antimicrobial, immune-stimulation, anti-inflammation and anti-tumour mechanisms. Moreover, local applications of honey in the treatment of different types of wounds have showed very promising outcomes. Diabetic foot disorder is a major complication in diabetic patients. It is the main cause of morbidity and disability. It often leads to amputations of foot. The potential benefits of honey in the treatment of diabetic foot disorder have been under study by researchers worldwide. The aim of this review is to summarize the reported local effects of honey on diabetic foot disorder and its possible mechanisms. The scientific findings indicate that honey can accelerate wound healing in diabetic foot disorder through its antimicrobial, anti-ulcerous and anti-inflammatory pathways in a clinical setting thus enhancing the quality of life in diabetic patients. However further research is needed to evaluate the molecular mechanisms of action and to standardize the use of honey in Diabetic foot disorder.
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References
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2. Al-Bukhaari M. Holy Hadith (Sahih Al-Bukhari, Arabic). 3rd ed. Chicago: Kazi Publications; 1994.
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10. Bansal V, Medhi B, Pandhi P. Honey-A remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J 2005;3:305–9.
11. White Jr. JW, Riethof ML, Subers MH, Kushnir I. Composition of American honeys. USDA Technical Bulletin 1962;1261(1):124.
12. Stanisˇkien B, Matusevicˇius P, Budreckien R. Honey as an indicator of environmental pollution. Aplinkostyrimaiinzˇinerijairvadyba (Environmental Research, Engineering and Management) 2006;2(36):53–8.
13. McKee B. Prevention of residues in honey: a future perspective. Apiacta 2003;38:173–7.
14. Tuzen M, Soylak M. Trace heavy metal levels in microwave digested honey samples from Middle Anatolia, Turkey. Journal of Food and Drug Analysis2005;13 (4):343–7.
15. Ashraf MW, Akram S. Characterization of Saudi Arabian floral honeys by their physicochemical characteristics and heavy metal contents. Fresenius Environmental Bulletin 2008;17(7b):877–81.
16. Sanford TM. Honey bees and environment contamination. Florida Extension Beekeeping Newsletter 1994;12 (5):15.
17. Zeisel SH. Choline: an essential nutrient for humans. Nutrition 2000;16:669–71.
18. Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: a Review. J Am Coll Nutr 2008;27:677–89.
19. Bogdanov S, Ruoff K, Persano Oddo L. Physico-chemical methods for the characterisation of unifloral honeys: a review. Apidologie 2007;35:S4–S17.
20. Tomás-Barberán FA, Martos I, Ferreres F, Radovic BS, Anklam E. HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys. J Sci Food Agric 2001;81:485–96.
21. Molan PC. The antibacterial activity of honey: The nature of the antibacterial activity. Bee World 1992;73(1):5–28.
22. Maeda Y, Loughrey A, Earle JAP, Millar BC, Rao JR, Kearns A. Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), Complementary Therapies in Clinical Practice 2008;14:77–82.
23. Mohamed SS, Al-Douri A. The effect of honey on the healing of oral ulcers (Clinical Study). Al-Rafidain Dent J 2008;8(2);157–60.
24. Molan PC. Honey as an antimicrobial agent, Bee Products. Properties, Applications, and Apitherapy, Symposium Tel Aviv 1997:27–37.
25. Al-Waili NS. Topical honey applications vs acyclovir for the treatment of recurrent herpes simplex lesions. Medical Science Monitor 2004;10:94–8.
26. Zeina B, Zohra BI, al-Assad S. The effects of honey on Leishmania parasites: an in vitro study. Trop Doct 2004;27(1):36–8.
27. Molan PC. The antibacterial activity of honey. 2: Variation in the potency of the antibacterial activity. Bee World 1992;73:59–76.
28. Bogdanov S. Nature and origin of the antibacterial substances in honey, Lebensm Wiss Technol 1997;30:748–53.
29. Molan PC. The role of honey in the management of wounds. J Wound Care 1999;8(8):415–8.
30. Olaitan PB, Adeleke OE, Ola LO. Honey: a reservoir for microorganisms and an inhibitory agent for microbs. Afr Health Sci 2007;7(3):159–64.
31. Sharp A. Beneficial effects of honey dressings in wound management. Nurs Stand 2007;24(7):66–74.
32. Jeffcoate W. The incidence of amputation in diabetes. Acta Chir Belg 2005;105:140–4.
33. Jennifer J, Eddy MD, Gideonsen MD. Topical honey for diabetic foot ulcers. J Fam Pract 2005;54(6):533–5.
34. Jull AB, Rodgers A, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2008;(4):CD005083.
35. Makhdoom A, Khan MS, Lagahari MA, Rahopoto MQ, Tahir SM, Siddiqui KA. Management of diabetic foot by naturalhoney. J Ayub Med Coll Abbottabad 2009;21(1):103–5.
36. McInerney RJ. Honey –a remedy rediscovered. J R Soc Med 1990;83(2):127.
37. Farouk A, Hassan T, Kashif H, Khalid SA, Mutawali I, Wadi M. Studies on Sudanese bee honey: laboratory and clinical evaluation. Int J Crude Drug Res 1988;26(3):161–8.
38. Efem SEE. Clinical observations on the wound healing properties of honey. Br J Surg 1988;75:679–81.
39. Rozaini MZ, Zuki ABZ, Noordin M, Norimah Y, Nazrul-Hakim A. The effects of different types of honey on tensile strength evaluation of burn wound tissue healing. Int J Appl Res Vet Med 2004;2(4):290–6.
40. Pieper B. Honey-Based Dressings and Wound Care. J Wound Ostomy Continence Nurs 2009;36(1):60–6.
41. Efem SEE. Recent advances in the management of Fournier’s gangrene: Preliminary observations. Surgery 1993;113(2):200–4.
42. Dumronglert E. A follow-up study of chronic wound healing dressing with pure natural honey. J Nat Res Counc Thail 1983;15(2):39–66.
43. Ndayisaba G, Bazira L, Habonimana E, Muteganya D. Clinical and bacteriological results in wounds treated with honey. J Orthop Surg 1993;7(2):202–4.
44. McInerney RJF. Honey –a remedy rediscovered. J R Soc Med 1990;83:127.
45. Molan PC. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2001;2(1):13–9.
46. Shukrimi A, Sulaiman AR, Halim AY, Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia 2008;63(1):44–6.
47. Moghazy AM, Shams ME, Adly OE, El-Badawy MA, Elsakka DM, Hassan SA, et al. The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes research and clinical practice 2010;89(3):276–81.
48. Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation, Dig Surg 2002;19:306–11.
49. Olaitan PB, Adeleke OE, Ola LO. Honey: a reservoir for microorganisms and an inhibitory agent for microbs. Afr Health Sci 2007;7(3):159–64.
50. Wadi M, Al-Amin H, Farouq A, Kashef H, Khaled SA. Sudanese bee honey in the treatment of suppurating wounds. Arab Medico 1987;3:16–8.
51. Subrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSite®) in the treatment of burns –a prospective randomised study. Br J Plast Surg 1993;46(4):322–3.
52. Tonks, A, Cooper RA, Price AJ, Molan PC, Jones KP. Stimulation of TNF-alpha release in monocytes by honey. Cytokine 2001;14(4):240–2.
2. Al-Bukhaari M. Holy Hadith (Sahih Al-Bukhari, Arabic). 3rd ed. Chicago: Kazi Publications; 1994.
3. Lusby PE, Coombes A, Wilkinson JM. Honey: a potent agent for wound healing J Wound Ostomy Continence Nurs 2002;29:295–300.
4. Phuapradit W, Saropala N. Topical application of honey in treatment of abdominal wound disruption. Aust N Z J Obstet Gynaecol 1992;32(4):381–4.
5. Alzahrani HA, Al-Amoudi MH, Bakhotmah BA. Top ten natural preparations for the treatment of diabetic foot disorders. Wounds UK 2010;6(4):18–26.
6. American Diabetic Association. Preventive foot care in patients with Diabetes. Diabet Care 2003;26:S78–9.
7. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007;117:1219–22.
8. Alzahrani HA, Bakhotmah BA. Top ten natural preparations for the treatment of diabetic foot disorders. Wounds UK 2010;6(4):18–26.
9. Al-jabri AA. Honey, milk and antibiotics. Afr J Biotechnol 2005;4:1580–7.
10. Bansal V, Medhi B, Pandhi P. Honey-A remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J 2005;3:305–9.
11. White Jr. JW, Riethof ML, Subers MH, Kushnir I. Composition of American honeys. USDA Technical Bulletin 1962;1261(1):124.
12. Stanisˇkien B, Matusevicˇius P, Budreckien R. Honey as an indicator of environmental pollution. Aplinkostyrimaiinzˇinerijairvadyba (Environmental Research, Engineering and Management) 2006;2(36):53–8.
13. McKee B. Prevention of residues in honey: a future perspective. Apiacta 2003;38:173–7.
14. Tuzen M, Soylak M. Trace heavy metal levels in microwave digested honey samples from Middle Anatolia, Turkey. Journal of Food and Drug Analysis2005;13 (4):343–7.
15. Ashraf MW, Akram S. Characterization of Saudi Arabian floral honeys by their physicochemical characteristics and heavy metal contents. Fresenius Environmental Bulletin 2008;17(7b):877–81.
16. Sanford TM. Honey bees and environment contamination. Florida Extension Beekeeping Newsletter 1994;12 (5):15.
17. Zeisel SH. Choline: an essential nutrient for humans. Nutrition 2000;16:669–71.
18. Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: a Review. J Am Coll Nutr 2008;27:677–89.
19. Bogdanov S, Ruoff K, Persano Oddo L. Physico-chemical methods for the characterisation of unifloral honeys: a review. Apidologie 2007;35:S4–S17.
20. Tomás-Barberán FA, Martos I, Ferreres F, Radovic BS, Anklam E. HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys. J Sci Food Agric 2001;81:485–96.
21. Molan PC. The antibacterial activity of honey: The nature of the antibacterial activity. Bee World 1992;73(1):5–28.
22. Maeda Y, Loughrey A, Earle JAP, Millar BC, Rao JR, Kearns A. Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), Complementary Therapies in Clinical Practice 2008;14:77–82.
23. Mohamed SS, Al-Douri A. The effect of honey on the healing of oral ulcers (Clinical Study). Al-Rafidain Dent J 2008;8(2);157–60.
24. Molan PC. Honey as an antimicrobial agent, Bee Products. Properties, Applications, and Apitherapy, Symposium Tel Aviv 1997:27–37.
25. Al-Waili NS. Topical honey applications vs acyclovir for the treatment of recurrent herpes simplex lesions. Medical Science Monitor 2004;10:94–8.
26. Zeina B, Zohra BI, al-Assad S. The effects of honey on Leishmania parasites: an in vitro study. Trop Doct 2004;27(1):36–8.
27. Molan PC. The antibacterial activity of honey. 2: Variation in the potency of the antibacterial activity. Bee World 1992;73:59–76.
28. Bogdanov S. Nature and origin of the antibacterial substances in honey, Lebensm Wiss Technol 1997;30:748–53.
29. Molan PC. The role of honey in the management of wounds. J Wound Care 1999;8(8):415–8.
30. Olaitan PB, Adeleke OE, Ola LO. Honey: a reservoir for microorganisms and an inhibitory agent for microbs. Afr Health Sci 2007;7(3):159–64.
31. Sharp A. Beneficial effects of honey dressings in wound management. Nurs Stand 2007;24(7):66–74.
32. Jeffcoate W. The incidence of amputation in diabetes. Acta Chir Belg 2005;105:140–4.
33. Jennifer J, Eddy MD, Gideonsen MD. Topical honey for diabetic foot ulcers. J Fam Pract 2005;54(6):533–5.
34. Jull AB, Rodgers A, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2008;(4):CD005083.
35. Makhdoom A, Khan MS, Lagahari MA, Rahopoto MQ, Tahir SM, Siddiqui KA. Management of diabetic foot by naturalhoney. J Ayub Med Coll Abbottabad 2009;21(1):103–5.
36. McInerney RJ. Honey –a remedy rediscovered. J R Soc Med 1990;83(2):127.
37. Farouk A, Hassan T, Kashif H, Khalid SA, Mutawali I, Wadi M. Studies on Sudanese bee honey: laboratory and clinical evaluation. Int J Crude Drug Res 1988;26(3):161–8.
38. Efem SEE. Clinical observations on the wound healing properties of honey. Br J Surg 1988;75:679–81.
39. Rozaini MZ, Zuki ABZ, Noordin M, Norimah Y, Nazrul-Hakim A. The effects of different types of honey on tensile strength evaluation of burn wound tissue healing. Int J Appl Res Vet Med 2004;2(4):290–6.
40. Pieper B. Honey-Based Dressings and Wound Care. J Wound Ostomy Continence Nurs 2009;36(1):60–6.
41. Efem SEE. Recent advances in the management of Fournier’s gangrene: Preliminary observations. Surgery 1993;113(2):200–4.
42. Dumronglert E. A follow-up study of chronic wound healing dressing with pure natural honey. J Nat Res Counc Thail 1983;15(2):39–66.
43. Ndayisaba G, Bazira L, Habonimana E, Muteganya D. Clinical and bacteriological results in wounds treated with honey. J Orthop Surg 1993;7(2):202–4.
44. McInerney RJF. Honey –a remedy rediscovered. J R Soc Med 1990;83:127.
45. Molan PC. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2001;2(1):13–9.
46. Shukrimi A, Sulaiman AR, Halim AY, Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia 2008;63(1):44–6.
47. Moghazy AM, Shams ME, Adly OE, El-Badawy MA, Elsakka DM, Hassan SA, et al. The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes research and clinical practice 2010;89(3):276–81.
48. Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation, Dig Surg 2002;19:306–11.
49. Olaitan PB, Adeleke OE, Ola LO. Honey: a reservoir for microorganisms and an inhibitory agent for microbs. Afr Health Sci 2007;7(3):159–64.
50. Wadi M, Al-Amin H, Farouq A, Kashef H, Khaled SA. Sudanese bee honey in the treatment of suppurating wounds. Arab Medico 1987;3:16–8.
51. Subrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSite®) in the treatment of burns –a prospective randomised study. Br J Plast Surg 1993;46(4):322–3.
52. Tonks, A, Cooper RA, Price AJ, Molan PC, Jones KP. Stimulation of TNF-alpha release in monocytes by honey. Cytokine 2001;14(4):240–2.
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Published
30-06-2013
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Al-Hariri MT. THE LOCAL EFFECTS OF HONEY ON DIABETIC FOOT DISORDER. Pak J Phsyiol [Internet]. 2013 Jun. 30 [cited 2024 Nov. 23];9(1):32-5. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/326
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