EFFECT OF TRIBULUS TERRESTRIS ON SERUM LUTEINIZING HORMONE IN SPRAGUE DAWLEY RATS

Authors

  • Sidra Hamid Department of Physiology, Rawalpindi Medical University, Rawalpindi, Pakistan.
  • Aneela Jamil Department of Biochemistry, Foundation University Medical College, Islamabad, Pakistan
  • Aneeqa Rashid Department of Physiology, Hitec Institute of Medical Sciences, Taxila, Pakistan
  • Qaiser Aziz Department of Medicine, Holy Family Hospital, Rawalpindi, Pakistan
  • Muhammad Aslam National University of Medical Sciences, Rawalpindi, Pakistan

Keywords:

luteinizing hormone (LH), Serum, Tribulus terrestris

Abstract

Background: Tribulus terrestris is a creeping herb that has been used in the past for treating impotence. The extract obtained from Tribulus mainly contains the active component protodioscin. Administration of the extract improves libido and spermatogenesis. Protodioscin increases the levels of luteinizing hormone (LH), testosterone, dehydroepiandrosterone (DHEA) and dihydrotestosterone (DHT). The objective of present study was to determine the effect of Tribulus terrestris on serum luteinizing hormone in male Sprague Dawley rats. Methods: The study was carried on 60 adult male Sprague Dawley rats aged 90–120 days and with average body weight of 200±50 grams. Rats were divided into two groups with 30 rats per group. Group A received 0.5 ml distilled water once daily orally. Group B was administered orally Tribulus aqueous extract 6 mg/Kg once daily. All the doses were given to rats for 8 weeks. After 8 weeks, serum luteinizing hormone was measured in both groups. The mean values of LH were compared using SPSS. Alpha value was kept at 0.05. Results: The mean LH level was 1.26±0.54 for control group while it was 1.75±0.65 for the experimental group. The difference between control group and experimental group was statistically significant (p<0.001). Conclusion: Tribulus terrestris increases the levels of LH when administered in appropriate doses.

Pak J Physiol 2017;13(4):38–40

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Published

31-12-2017

How to Cite

1.
Hamid S, Jamil A, Rashid A, Aziz Q, Aslam M. EFFECT OF TRIBULUS TERRESTRIS ON SERUM LUTEINIZING HORMONE IN SPRAGUE DAWLEY RATS. Pak J Phsyiol [Internet]. 2017 Dec. 31 [cited 2024 Apr. 25];13(4):38-40. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/287

Issue

Vol. 13 No. 4 (2017): Pakistan Journal of Physiology

Section

Original Article

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Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, cited and quoted with full reference of, and acknowledgement to the PJP.