CORRELATION OF TUMOUR NECROSIS FACTOR-α WITH OBESITY INDUCED INSULIN RESISTANCE IN TYPE 2 DIABETES MELLITUS

Authors

  • Farhat Ijaz Department of Physiology, CMH Lahore Medical College
  • Rana Khurram Aftab , Assistant Professor, Department of Physiology, King Edward Medical University, Lahore
  • Syed M. Zubair Department of Physiology, King Edward Medical University, Lahore
  • Rana Rakhshan Aftab Rashid Latif Medical College, Lahore, Pakistan

DOI:

https://doi.org/10.69656/pjp.v14i2.228

Keywords:

Insulin Resistance, Obesity, Type 2 Diabetes Mellitus, Tumour Necrosis Factor Alpha

Abstract

Background: Obesity is a major cause of many metabolic disorders characterized by chronic inflammation that is linked with T2DM and insulin resistance. Tumour Necrosis Factor Alpha (TNF-α) is remarkably higher in obese people. The aim of this study was to determine the levels of TNF-α and its correlation with insulin resistance and body mass index in type 2 diabetic patients. Methods: This study was conducted at Diabetic Clinic of Mayo Hospital, Lahore. TNF-α levels were determined and correlated with insulin resistance and body mass index in 90 obese type 2 diabetics. TNF-α and serum insulin were determined using ELISA. Insulin resistance was calculated by HOMA-IR. Pearson correlation test was used to correlate TNF-α with Insulin Resistance and body mass index, and p≤0.05 was considered statistically significant. Results: There was a strong positive correlation of fasting insulin and HOMA-IR with TNF-α (r=0.986, p<0.001). There was also strong positive correlation of TNF-α with BMI. Conclusion: Increased inflammation in obese diabetics explains the role of TNF-α in insulin resistance caused by obesity. Weight reduction in obese individuals will help in reducing TNF-α levels and to improve insulin sensitivity in T2DM.

Pak J Physiol 2018;14(2):18–20

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Pak J Physiol 2018;14(2)

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Published

30-06-2018

How to Cite

1.
Ijaz F, Aftab RK, Zubair SM, Aftab RR. CORRELATION OF TUMOUR NECROSIS FACTOR-α WITH OBESITY INDUCED INSULIN RESISTANCE IN TYPE 2 DIABETES MELLITUS. Pak J Phsyiol [Internet]. 2018 Jun. 30 [cited 2024 Nov. 23];14(2):18-20. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/228

Issue

Vol. 14 No. 2 (2018): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.