EFFECT OF ALMONDS AND ATENOLOL ON SERUM LUTEINIZING HORMONE LEVEL IN MALE BALB-C MICE

Authors

  • Irum Rehman Margalla Institute of Health Scienes, Rawalpindi
  • Shakir khan
  • ifra ashraf
  • ayesha naveed
  • farheen masood

DOI:

https://doi.org/10.69656/pjp.v14i3.203

Keywords:

Keywords: Prunus Amygdalis, Almonds Atenolol, Luteinizing hormone.

Abstract

Background: Along with other advantageous effects nuts are good for fertility and can improve derangements in different fertility parameters. With increasing incidence of hypertension leading to an increase in consumption of antihypertensives it is inevitable to depart their side effects. This study was designed to see the effect of administration of Prunus amygdalus, atenolol and combination of atenolol and Prunus amygdalus on level of serum luteinizing hormone (LH) in male Balb-C mice. Methods: This experimental study was conducted from December 2013 to June 2014. One hundred and twenty mice fulfilling inclusion criteria were divided into 4 groups of 30 mice each. Group A served as control group, group B mice were given atenolol, group C mice were given extract of almonds and group D mice were given atenolol and almonds. After the completion of 3 months, blood sampling was done and serum LH was measured. Data was analyzed on SPSS-17, Mean±SD was calculated for luteinizing hormone levels. One-way ANOVA was applied and p≤0.05 was considered significant. Results: The mean value of serum LH in group B (Atenolol treated) was found to be significantly elevated. In group C (Almonds) serum LH was decreased but not significantly. Mean serum LH level in group D (Atenolol+Almond) was raised as compared to control group, but not significantly. Conclusion: Administration of Prunus amygdalis does not affect serum LH but atenolol causes a rise in serum LH.

Downloads

Download data is not yet available.

References

1. Cardoso BR, Duarte GBS, Reis BZ, Cozzolino SMF. Brazil nuts: Nutritional composition, health benefits and safety aspects. Food Res Int 2017;100:9–18.
2. Miller MG, Thangthaeng N, Poulose SM, Shukitt-Hale B. Role of fruits, nuts, and vegetables in maintaining cognitive health. Exp Gerontol 2017;94:24–8.
3. Dhingra N, Kar A, Sharma R, Bhasin S. In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds. S Afr J Bot 2017;108:184–92.
4. Johnstona CS, Sweazeab KL, Schwaba E, McElaney EA. Almond ingestion contributes to improved cardiovascular health in sedentary older adults participating in a walking intervention: A pilot study. J Funct Foods 2017;39:58–62.
5. Zhu Y, Wilkinson KL, Wirthensohn MG. Lipophilic antioxidant content of almonds (Prunus dulcis): A regional and varietal study. J Food Compos Anal 2015;39:120-7.
6. Dhillon J, Tan SY, Mattes RD. Effects of almond consumption on the post-lunch dip and long-term cognitive function in energy-restricted overweight and obese adults. Br J Nutr 2017;117:395–402.
7. Berk L, Lohman E, Bains G, Bruhjell K, Bradburn J, Vijayan N, et al. Nuts and brain health: Nuts increase EEG power spectral density (μV& [sup2]) for delta frequency (1–3Hz) and Gamma Frequency (31–40 Hz) associated with deep meditation, empathy, healing, as well as neural synchronization, enhanced cognitive processing, recall, and memory all beneficial for brain health. FASEB J 2017;31(1 Suppl):624–36.
8. Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci 2018;19:70–91.
9. Gallier S, Singh H. Behavior of almond oil bodies during in vitro gastric and intestinal digestion. Food Funct 2012;3:547–55
10. Rajput MY. Comparing traditional and medical treatments for constipation : A Review Article. World Fam Med J. 2017; 15(9):124–7.
11. Nawaz A, Jan SU, Khan NR, Hussain A, Khan GM. Formulation and in vitro evaluation of clotrimazole gel containing almond oil and tween 80 as penetration enhancer for topical application. Pak J Pharm Sci 2013;26:617–22.
12. Quan H, Khan N, Hemmelgarn BR, Tu K, Chen G, Campbell N, et al. Validation of a case definition to define hypertension using administrative data. Hypertension 2009;54:1423–8.
13. Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control a systematic analysis of population-based studies from 90 countries. Circulation 2016;134:441–50.
14. Blumenthal JA, Sherwood A, Smith PJ, Mabe S, Watkins L, Lin PH, et al. Lifestyle modification for resistant hypertension: The TRIUMPH randomized clinical trial. Am Heart J 2015;170:986–94.
15. Kuyper LM, Khan NA. Atenolol vs nonatenolol β-blockers for the treatment of hypertension: a meta-analysis. Can J Cardiol 2014;30(5 Suppl):S47–53.
16. Khan UA, Aslam M, Saeed SA. Effect of beta adrenergic antagonist on the production of testosterone by rat's Leydig cells. J Ayub Med Coll Abbottabad 2004;16(4):26–8.
17. el-Sayed MG, el-Sayed MT, Elazab Abd el S, Hafeiz MH, el-Komy AA, Hassan E. Effects of some beta-adrenergic blockers on male fertility parameters in rats. Dtsch Tierarztl Wochenschr 1998;105:10–2.
18. Qureshi S, Shah AH, Tariq M, Ageel AM. Studies on herbal aphrodisiacs used in Arab system of medicine. Am J Chin Med 1989;17(1-2):57–63.
19. Weick RF. Acute effects of adrenergic receptor blocking drugs and neuroleptic agents on pulsatile discharges of luteinizing hormone in the ovariectomized rat. Neuroendocrinology 1978;26:108–17.
20. Al-Mehmood MH, Gilmore DP, Wilson CA, Tuohy-Jones P, Drummond S, Gopalan C. The role of the hypothalamic beta-adrenergic system in controlling the LH rise in short-term castrated rats. J Endocrinol 1987;114:167–72.
21. Naveed AK, Ali L, Minhas LA, Tahir M. Effects of propranolol on testosterone in adult rats. Pak Armed Forces Med J 2008;58(1):51–6.
22. Nusier MK, Bataineh HN, Daradka HM. Adverse effects of propranolol on reproductive function in adult male mice. Pak J Biol Sci 2007;10:2728–31.
23. Mokhtari M, Abedinzadeh M, Naseran SN. Effect of walnut (juglans regia) extract on serum LH, FSH and testosterone levels in adult male rat. J Ardabil Univ Med Sci 2012;12:157–65.
24. El-Khamisy AE, Rezq AA. hypoglycemic effect of hazelnut and its effect on some sex hormones in alloxan induced diabetic in female rats. Pak J Nutr 2013;12:229–38.
Pak J Physiol 2018;14(3)

Downloads

Published

14-08-2018

How to Cite

1.
Rehman I, khan S, ashraf ifra, naveed ayesha, masood farheen. EFFECT OF ALMONDS AND ATENOLOL ON SERUM LUTEINIZING HORMONE LEVEL IN MALE BALB-C MICE. Pak J Phsyiol [Internet]. 2018 Aug. 14 [cited 2024 Nov. 21];14(3):37-40. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/203

Issue

Vol. 14 No. 3 (2018): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.