COMPARISON OF PERIAPICAL HEALING FOLLOWING NON-SURGICAL ROOT CANAL TREATMENT VS INJECTABLE PLATELET RICH FIBRIN IN REGENERATIVE ENDODONTIC TREATMENT OF NECROTIC IMMATURE PERMANENT ANTERIOR TEETH

Authors

  • Hira Anmol
  • Mustafa Sajid
  • Amina Ghaffar
  • Muhammad Ahmad
  • Amira Shahid
  • Amara Nazir
  • Afsheen Mansoor
  • Mudassar Mushtaq Jawad Abbasi

DOI:

https://doi.org/10.69656/pjp.v21i4.1920

Keywords:

Endodontic treatment, Healing, Injectable platelet-rich fibrin, Tooth

Abstract

Background: Necrosis of dental pulp can act as bacterial ingression source causing periapical infection leading to tooth loss. Regenerative Endodontics is the desired technique for replacing damaged pulpal structures with normal physiology and function. Objective of this study was to compare the periapical healing following non-surgical root canal treatment using blood clot formation versus regenerative endodontic treatment utilizing injectable platelet-rich fibrin (i-PRF) in necrotic immature permanent anterior teeth. Methods: This comparative study was conducted at Department of Operative Dentistry, Bakhtawar Amin Dental Hospital, Multan, from May 2023 to April 2024. A total of 164 patients meeting the inclusion criteria were recruited and randomly assigned into two groups: Group-I (blood clot scaffold) and Group-II (i-PRF scaffold), with 82 patients each. Standardized clinical protocols were followed for canal disinfection and scaffold placement. Results: Both groups showed significant improvement over time; however, Group II (i-PRF) demonstrated a significantly greater reduction in periapical lesion size compared to Group-I at all follow-up intervals (p<0.05). At 12 months, the mean lesion perimeter was 5.6±4.7 mm² in Group-I and 2.8±3.5 mm² in Group-II (p<0.001). The i-PRF group exhibited faster clinical symptom resolution and a higher rate of complete radiographic healing (86.6% vs 73.2%). Conclusion: Injectable platelet-rich fibrin significantly improves clinical and radiographic healing outcomes compared to traditional blood clot induction in regenerative endodontic treatment of necrotic immature permanent anterior teeth, and provides a biologically active scaffold, enhancing the regenerative potential of endodontic therapies.

Pak J Physiol 2025;21(4):40–3, DOI: https://doi.org/10.69656/pjp.v21i4.1920

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Published

31-12-2025

How to Cite

1.
Anmol H, Sajid M, Ghaffar A, Ahmad M, Shahid A, Nazir A, et al. COMPARISON OF PERIAPICAL HEALING FOLLOWING NON-SURGICAL ROOT CANAL TREATMENT VS INJECTABLE PLATELET RICH FIBRIN IN REGENERATIVE ENDODONTIC TREATMENT OF NECROTIC IMMATURE PERMANENT ANTERIOR TEETH. Pak J Phsyiol [Internet]. 2025 Dec. 31 [cited 2026 Jan. 27];21(4):40-3. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1920

Issue

Vol. 21 No. 4 (2025): Pakistan Journal of Physiology

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Original Article

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Copyright (c) 2025 Hira Anmol, Mustafa Sajid, Amina Ghaffar, Muhammad Ahmad, Amira Shahid, Amara Nazir, Afsheen Mansoor, Mudassar Mushtaq Jawad Abbasi

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