THE IMMUNOMODULATORY POTENTIAL: ANTIPSYCHOTICS WITH VITAMIN D AND E INTERPLAY ON INTERFERON GAMMA AND TUMOUR NECROTIC FACTOR ALPHA

Authors

  • Muhammad Abid Department of Pharmacology, Bolan Medical College, Quetta, Pakistan
  • Hazrat Ali Department of Psychiatry, Baluchistan Institute of Psychiatry and Behavioral Sciences, Quetta, Pakistan
  • Shereen Khan Department of Dermatology, Bolan Medical College, Quetta, Pakistan
  • Rabia Arshad Altamash Institute of Dental Medicine, Karachi, Pakistan https://orcid.org/0000-0001-5805-7163
  • Zubaida Anwar Department of Biochemistry, Bolan Medical College, Quetta, Pakistan
  • Azhar Memon Department of Medicine, Suleman Roshan Medical College, Tando Adam, Pakistan

Keywords:

Vitamin E, vitamin D, Antipsychotics, Tumour Necrosis Factor Alpha, interferon

Abstract

Background: Interferon-gamma (IFN-?) and Tumour Necrotic Factor-alpha (TNF-?) are important immunomodulators raised in psychiatric illnesses. This study is aimed to determine the effects of antipsychotic drugs alone and in combination with vitamin D and E on inflammatory cytokines IFN-? and TNF-? level in psychotic patients. Methods: An ERB-approved (NCT 06200584), randomized control trial was carried out from Jan to Jun 2021 at the Baluchistan Institute of Psychiatry and Behavioural Sciences, Quetta, Pakistan. With non-probability purposive sampling, a total of 260 were enrolled. Group-1 had healthy controls while group-2, 3 and 4 had psychotic patients on olanzapine (10 mg/day), risperidone (2 mg/day) or quetiapine (100 mg/day) respectively. Patients in groups 5, 6 and 7 were kept on recommended risperidone, olanzapine or quetiapine respectively with added vitamin D (200,000 IU once weekly) and Vitamin E (400 mg daily). After two months, the blood samples were analysed for IFN-? and TNF-?. The results were tabulated with SPSS-26 for 35 patients in each group who completed the study. Results: The groups treated with antipsychotics had statistically higher IFN-? and TNF-? expression than the control group (p<0.001). The combination of antipsychotics with added Vitamin D and Vitamin E led to a significant reduction in IFN-? and TNF-? (p<0.001) with maximum decrease with quetiapine in combination with Vitamin D and E. Conclusion: Antipsychotics increase IFN-? and TNF-? expression. The combination therapy across various antipsychotic treatment groups with added Vitamin D and E resulted in lower IFN-? and TNF-?.

Pak J Physiol 2024;20(3):8?12 DOI: https://doi.org/10.69656/pjp.v20i3.1691

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Author Biographies

Muhammad Abid, Department of Pharmacology, Bolan Medical College, Quetta, Pakistan

Associate Professor, Department of Pharmacology, Bolan Medical College, Quetta, Pakistan

Hazrat Ali, Department of Psychiatry, Baluchistan Institute of Psychiatry and Behavioral Sciences, Quetta, Pakistan

Associate Professor, Psychiatry Department, Baluchistan Institute of Psychiatry and Behavioral Sciences, Quetta, Pakistan

Shereen Khan, Department of Dermatology, Bolan Medical College, Quetta, Pakistan

Assistant Professor, Dermatology Department, Bolan Medical College, Quetta, Pakistan

Zubaida Anwar, Department of Biochemistry, Bolan Medical College, Quetta, Pakistan

Associate Professor, Department of Biochemistry, Bolan Medical College, Quetta, Pakistan

Azhar Memon, Department of Medicine, Suleman Roshan Medical College, Tando Adam, Pakistan

Professor, Department of Medicine, Suleman Roshan Medical College, Tando Adam, Pakistan

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Published

30-09-2024

How to Cite

1.
Abid M, Ali H, Khan S, Arshad R, Anwar Z, Memon A. THE IMMUNOMODULATORY POTENTIAL: ANTIPSYCHOTICS WITH VITAMIN D AND E INTERPLAY ON INTERFERON GAMMA AND TUMOUR NECROTIC FACTOR ALPHA. Pak J Phsyiol [Internet]. 2024 Sep. 30 [cited 2024 Oct. 6];20(3):8-12. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1691