EFFICACY OF ENHANCED PREOPERATIVE MANAGEMENT FOR NON-PROGRESSION IN MEIBOMIAN GLAND DYSFUNCTION AFTER CATARACT SURGERY: A RANDOMIZED CONTROLLED TRIAL

Authors

  • Bushra Aaqil Department of Ophthalmology, Ayub Teaching Hospital, Abbottabad, Pakistan
  • Zainab Nazneen Department of Community Medicine, Ayub Medical College, Abbottabad, Pakistan
  • Afsheen Siddiqui Department of Pharmacology, Ayub Medical College, Abbottabad, Pakistan
  • Rifat Latif Department of Anaesthesia, Ayub Teaching Hospital, Abbottabad, Pakistan
  • Mahrukh Ali Department of Ophthalmology, Ayub Teaching Hospital, Abbottabad, Pakistan
  • Rameesha Habib Department of Ophthalmology, Ayub Teaching Hospital, Abbottabad, Pakistan
  • Hasan Sajid Kazmi Department of Ophthalmology, Ayub Teaching Hospital, Abbottabad, Pakistan

DOI:

https://doi.org/10.69656/pjp.v20i2.1674

Keywords:

Dysfunction, Meibomian Gland, Preoperative

Abstract

Background: Cataract surgery may alter proper functioning of meibomian glands and result in worsening of glandular dysfunction. The role of combined postop and routine 3 days preoperative treatment of meibomian gland disease (MGD) after cataract surgery has been studied but the role of enhanced 2 weeks preoperative treatment has yet to be evaluated. The objective of this study was to compare the efficacy of enhanced preoperative treatment for 2 weeks and routine preoperative treatment for 3 days alone in non-progression of MGD to severe stages after cataract surgery. Methods: This randomized controlled study was conducted at Ophthalmology Department, Ayub Teaching Hospital Abbottabad from 1st March 2022 to 31st July 2023. The sample size was 150 eyes (75 in each group) selected using consecutive sampling. Group A was given enhanced 2 weeks preoperative treatment while the group B was given routine 3 days pre-operative treatment only. Success of pre-operative treatment was regarded as non-progression to severe stages postoperatively from baseline. Data analysis was done using SPSS-24. Results: The efficacy of enhanced 2 weeks preoperative treatment was 69 (87.3%) at 1 month, and 67 (82.7%) at 3 months follow-up while efficacy of routine 3 days preoperative treatment alone was 10 (12.7%) and 14 (17.3%) at 1 and 3 months respectively with a significant difference between the groups (p<0.001). Conclusion: Enhanced 2 weeks preoperative treatment was superior to routine 3 days preoperative treatment alone in non-progression of MGD to severe stages after cataract surgery.

Pak J Physiol 2024;20(2):58-60

Downloads

Download data is not yet available.

References

Gurnani B, Kaur K. Meibomian Gland Disease. StatPearls [Internet]. 2022 Dec 6 [cited 2023 Jun 2]; Available from: https://www.statpearls.com/ArticleLibrary/viewarticle/143508

Yeotikar NS, Zhu H, Markoulli M, Nichols KK, Naduvilath T, Papas EB. Functional and morphologic changes of Meibomian glands in an asymptomatic adult population. Invest Ophthalmol Vis Sci 2016;57(10):3996–4007.

El Ameen A, Majzoub S, Vandermeer G, Pisella PJ. Influence of cataract surgery on Meibomian gland dysfunction. J Fr Ophtalmol 2018;41(5):e173–80.

Han KE, Yoon SC, Ahn JM, Nam SM, Stulting RD, Kim EK, et al. Evaluation of dry eye and meibomian gland dysfunction after cataract surgery. Am J Ophthalmol 2014;157(6):1144–50.e1.

Ha M, Kim JS, Hong SY, Chang DJ, Whang WJ, Na KS, et al. Relationship between eyelid margin irregularity and meibomian gland dropout. Ocul Surf 2021;19:31–7.

Sabeti S, Kheirkhah A, Yin J, Dana R. Management of meibomian gland dysfunction: a review. Surv Ophthalmol 2020;65(2):205–17.

Song P, Sun Z, Ren S, Yang K, Deng G, Zeng Q, et al. Preoperative management of MGD alleviates the aggravation of MGD and dry eye induced by cataract surgery: A prospective, randomized clinical trial. Biomed Res Int 2019;2019:2737968.

Park J, Yoo YS, Shin K, Han G, Arita R, Lim DH, et al. Effects of lipiflow treatment prior to cataract surgery: A prospective, randomized, controlled study. Am J Ophthalmol 2021;230:264–75.

Matossian C, Chang DH, Whitman J, Clinch TE, Hu J, Ji L, et al. preoperative treatment of meibomian gland dysfunction with a vectored thermal pulsation system prior to extended depth of focus IOL implantation. Ophthalmol Ther 2023;12:2427–39.

Den S, Shimizu K, Ikeda T. Prevalence of meibomian gland dysfunction and its relationship with age, gender, and tear function. Inves Ophthalmol Vis Sci 2003;44(13):2469.

Kwan JT, Opitz DL, Hom MM, Paugh JR. Gender differences in a meibomian gland dysfunction-specific symptom questionnaire. Inves Ophthalmol Vis Sci 2014;55(13):22.

Downloads

Published

30-06-2024

How to Cite

1.
Aaqil B, Nazneen Z, Siddiqui A, Rifat Latif, Mahrukh Ali, Habib R, et al. EFFICACY OF ENHANCED PREOPERATIVE MANAGEMENT FOR NON-PROGRESSION IN MEIBOMIAN GLAND DYSFUNCTION AFTER CATARACT SURGERY: A RANDOMIZED CONTROLLED TRIAL. Pak J Phsyiol [Internet]. 2024 Jun. 30 [cited 2024 Oct. 29];20(2):58-60. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1674

Issue

Vol. 20 No. 2 (2024): Pakistan Journal of Physiology

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, projected, cited and quoted with full reference of, and acknowledgement to the author(s) and the PJP. The contents are published with an international CC-BY-ND-4.0 License.