ASSOCIATION OF SMOKING WITH PROSTATE CANCER IN OLD AGE PAKISTANI MALES WITH TMPRSS2 GENE POLYMORPHISM (rs12329760)

Authors

  • Saadia Sadiq Department of Biochemistry, Abbottabad International Medical College, Abbottabad, Pakistan
  • Sarwat Abbasi Department of Biochemistry, Ayub Medical College, Abbottabad, Pakistan
  • Bushra Rehman Department of Biochemistry, Foundation University Medical College, Islamabad, Pakistan
  • Sahar Ikram Department of Biochemistry, Federal Medical and Dental College, Islamabad, Pakistan
  • Anwar Shahzad Department of Community Medicine, Abbottabad International Medical College, Abbottabad, Pakistan
  • Tehseen Ashraf Kohistani Department of Medicine, Combined Military Hospital, Bahawalpur, Pakistan

DOI:

https://doi.org/10.69656/pjp.v20i2.1656

Keywords:

Prostate Caner, Polymerase Chain Reaction, Smoking, TMPRSS2 Gene

Abstract

Background: Second most common cause of cancer related deaths in men is prostate cancer. Obesity, old age and smoking are the common modifiable risk factors for this cancer. Smoking and prostate cancer together can lead to higher mortality rate, especially in heavy smokers. TMPRSS2 gene polymorphism (rs12329760) is also associated with this cancer in smokers. This study was conducted to find out the association of smoking with prostate cancer patients with TMPRSS2 gene polymorphism (rs12329760) in old age Pakistani men. Methods: It was a case control study conducted from Oct 2021 to Sep 2022 in Railway Hospital, Rawalpindi, and Urology Department, National Institute of Rehabilitative Medicine, Islamabad. Sample size was 200 with 100 prostate cancer cases and 100 age-matched controls. Chelax method was used for DNA extraction from blood samples. Polymerase Chain Reaction (PCR) was carried out to find out the relationship of smoking with prostate cancer development with TMPRSS2 gene polymorphism (rs12329760). Results: Significant association was found in smokers in age group 76-100 years with CT-genotype of TMPRSS2 gene polymorphism (rs12329760) in cases (p<0.001). Conclusion: Smoking is a modifiable risk factor for development of prostate cancer with TMPRSS2 gene polymorphism (rs12329760) in old age Pakistani men.

Pak J Physiol 2024;20(2):54-7

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Published

30-06-2024

How to Cite

1.
Sadiq S, Abbasi S, Rehman B, Ikram S, Shahzad A, Kohistani TA. ASSOCIATION OF SMOKING WITH PROSTATE CANCER IN OLD AGE PAKISTANI MALES WITH TMPRSS2 GENE POLYMORPHISM (rs12329760). Pak J Phsyiol [Internet]. 2024 Jun. 30 [cited 2024 Nov. 23];20(2):54-7. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1656

Issue

Vol. 20 No. 2 (2024): Pakistan Journal of Physiology

Section

Original Article

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