FREQUENCY AND MORPHOLOGICAL PATTERNS OF CNS TUMORS IN A TERTIARY CARE HOSPITAL OF SOUTH PUNJAB
DOI:
https://doi.org/10.69656/pjp.v20i2.1648Keywords:
astrocytoma, Oligodendroglioma, Meningioma, Schwannoma, Ependymoma, Medulloblastoma, CraniopharyngiomaAbstract
Background: The incidence of CNS tumours is increasing rapidly especially in young population. CNS tumours include a set of neoplasms which originate form brain parenchyma, pituitary gland, pineal gland, spinal cord and meninges. The aim of this study was to observe the frequency and morphological patterns of CNS tumours in a tertiary care hospital of South Punjab. Methods: A cross-sectional descriptive study of 100 cases of brain tumours was conducted at the Pathology Department of DG Khan Medical College, Dera Ghazi Khan. One-hundred cases of CNS tumour biopsies were included with the relevant clinical and radiological findings. Results: A total of 100 cases of CNS tumours were studied. The morphological distribution of various CNS tumours was as follows: Astrocytoma (49%), Meningioma (19%), Schwannoma (8%), Oligodandroglioma (6%), Metastatic tumour (4%), Ependymoma (4%), Pituitary Adenoma (2%), Medulloblastoma (2%), Mixed Gliomas (2%), Germ Cell Tumours (1%), Craniopharyngioma (1%), Lymphoma (1%), Vascular tumours (1%). Conclusion: Among the CNS tumours Astrocytomas were the commonest tumours followed by Meningiomas, Schwannoma and Oligodendroglioma.
Pak J Pathol 2024;20(2):24-6
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References
Frosch PM, Anthony CD, Girolami UD. The central nervous system. In Kumar V, Abbas AK, Fausto N, Aster JC, (Eds). Robbins and Cotran pathologic basis of diseases. 8th ed. Philadelphia: Elsevier; 2010.p. 1330.
Danish F, Salam H, Qureshi MA, Nouman M, Comparative clinical and epidemiological study of central nervous system Tumours in Pakistan and global database, Interdiscip Neurosurg 2021;25:101239,
Robbins S, Cotran R. Diseases of the immune system. In: Kumar V, Abbas AK, Fausto N, Aster JC, (Eds). Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia: Elsevier: 2013. p. 842–9.
Ahsan J, Hashmi SN, Mohammad I, Din HU, Butt AM, Nazir S, et al. Spectrum of CNS Tumours -A single center histopathological review of 761 cases over 5 years. J Ayub Med Coll Abbottabad 2015;27(1):81–4.
Sajjad M, Shah H, Khan Z A, Ullah S. Histopathological pattern of intracranial tumours in a tertiary care hospital of Peshawar, Pakistan. J Sheikh Zayed Med Coll 2015;7(1):909–12.
Mohan H, (Ed). Text book of Pathology. 6th ed. New Delhi: JAPEE; 2010,p. 866.
Jamal A, Seige lR, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics 2009. CA Cancer J CIin 2009;59(4):225–49.
Stevens GHJ. Brain Tumours: Meningiomas and Gliomas. 2010. Available from https://teachmemedicine.org/cleveland-clinic-brain-tumors-meningiomas-and-gliomas/
Patil S, Perry A. Central Nervous System: Brain Spinal cord and Meninges. In: The Washington Manual of Surgical Pathology. 1st ed. New Delhi: Wolters Kluwer; 508–40.
Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY, Olson JJ. Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J Clin 2010;60(3):166–93.
Stevens A. The haematoxylin. In: Bancroft JD, Stevens A (Eds). Theory and Practice of Histological Techniques. 3rd ed. Edinburgh: Churchill Livingstone 1990.p. 107–17.
Bancroft JD, Gamble M. Theory and practice of histological techniques. 5th ed. London: Churchill Livingstone; 2002.p. 127–8.
Ahmed Z, Muzaffar S, Kayani N, Pervez S, Husainy AS, Hasan SH. Histopathological pattern of central nervous system neoplasm. J Pak Med Assoc 2001;51(4):154–7.
Dogar T, lmran AA, Hasan M, Jaffar R, Bajwa R, Qureshi ID. Space occupying lesions of central nervous system: A radiological and histopathological correlation. Biomedica 2015;31(1):15–20.
Aryal G. Histopathological pattern of central nervous system tumour: A three-year retrospective study. J Pathol Nepal 2011;1(1):22–5.
Adnan HA, Kambhoh UA, Majeed S, et al. Frequency of CNS lesions in a tertiary care hospital–A 5 year study. Biomedica 2017;33(1):4–8.
Nibhoria S, Tiwana KK, Phutela R, Bajaj A, Chhabra S, Bansal S. Histopathological spectrum of central nervous system tumours: a single centre study of 100 cases. Int J Sci Stud 2015;3(6):130–4.
Masoodi T, Gupta RK, Singh JP, Khajuria A. Pattern of central nervous system neoplasm: A study of 106 cases. JK Pract 2012;17:42–6.
Chen L, Zou X, Wang Y, Mao Y, Zhou L. Central nervous system tumours: a single center pathology review of 34,140 cases over 60 years. BMC Clin Pathol 2013;13(1):14.
Vimal S, Dharwadker A, Vishwanathan V, Agarwal N, Histo-pathological spectrum of central nervous system tumours in a tertiary care center. Indian J Pathol Res Pract 2020;9(2 Pt-1):105–10.
Butt ME, Khan SA, Chaudhry NA, Qureshi GR. Intra-cranial space occupying lesions –A morphological analysis. Biomedica 2005; 21(1):31–5.
Lakshmi K, Hemalatha M, Sunkesula SB, Arasi TDS, Rao LB. Histopathological study of spectrum of the lesions of central nervous system in a tertiary care hospital. J Evol Med Dent Sci 2015;4(7):1145–50.
Ghanghoria S, Mehar R, Kulkarni CV, Mittal M, Yadav A, Patidar H. Retrospective histologicalanalysis of CNS tumors. A 5-year study. IntJ Med Sci Public Health 2014;3(10):1205–7.
Jaffar R, Dogar T, Qureshy A, Qureshi N, Central nervous system tumours. A study of frequency and morphology. J Fatima Jinnah Med Univ 2011;5(2):116–8.
Ali N, Ikram M, Khan TS, Enam SA, Jangda AQ, Karsan F, Extracranial meningioma: an unusual presentation of a mass over inner canthus of left eye. J Col Physicians Surg Pak 2011;21(5):309–10.
Awan MS, Qureshi HU, Sheikh AA, Ali MM. Vestibular schwannomas: clinical presentation, management and outcome. J Pak Med Assoc 2001;51(2):63–7.
Pidakala P, Inuganti RV, Boregowda C, Mathi A, Lakhineni S. A five year histopathological review of CNS tumours in a tertiary centre with emphasis on diagnostic aspects of uncommon tumours. J Evid Based Med Healthc 2016;3(51):2605–12.
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