EFFECTS OF CHEWING TIME OF HIGH PROTEIN MEAL ON SATIETY AND GLP-1 HORMONE

Authors

  • Ayesha Sardar Department of Physiology, Rehman College of Dentistry, Peshawar, Pakistan
  • Inayat Shah Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan
  • Omar Malik Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan
  • Rashid Mahmood Department of Physiology, Rehman Medical College, Rehman Medical Institute, Peshawar, Pakistan
  • Aamir Asmatullah Department of Physiology, Kabir Medical College, Gandhara University, Peshawar, Pakistan
  • Owais Qaisar

DOI:

https://doi.org/10.69656/pjp.v20i2.1632

Keywords:

Glucagon-like Peptide 1, Chewing time, Satiety, High Protein Meal, VAS, LMS

Abstract

Background: Chewing or mastication process affects satiety as well as satiety regulating hormone Glucagon-like Peptide-1 (GLP-1). Proteins have the highest satiating effects among the macronutrients. This study explored the association of chewing with satiety and GLP-1 in participants consuming high-protein meal. Methods: Fifteen healthy volunteers, aged 25-35 years were enrolled through random sampling. Effects of chewing on postprandial satiety and plasma GLP-1 was examined through quasi-experimental study conducted in Khyber Medical University, Peshawar, from Jan to Mar 2023. Three visits were designed with one week wash-out period. Satiety and GLP-1 were compared among normal, fast, and slow chewing conditions, while providing high protein meal. Subjective satiety was assessed via visual analogue scale (VAS) and labelled magnitude scale (LMS), while serum GLP-1 levels were analysed through ELISA at baseline, 30, 120 and 240 min in each visit. Results: The participants had a mean chewing time of 793.66±311 second at normal rate. Mean chewing time was decreased to 496.60±135.82 second during fast chewing, while significantly increased to 1459.66±400.83 second during slow chewing. A comparison of satiety at different chewing rates revealed that slow chewing significantly reduced hunger and enhanced fullness (p<0.05), relative to normal and fast chewing, at 240 minutes (p<0.05). However, no significant difference was observed in plasma GLP-1 levels at any time intervals (p>0.05). Conclusion: Satiety is significantly influenced by chewing and number of chews per bite of a high protein meal, whereas postprandial plasma GLP-1 levels show no significant differences across different chewing rates.

Pak J Physiol 2024;20(2):31-35

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References

Lin X, Li H. Obesity: epidemiology, pathophysiology, and therapeutics. Front Endocrinol (Lausanne) 2021;12:585887.

GBD 2015 Obesity Collaborators: Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 2017;377(1):13–27.

Kolahi AA, Moghisi A, Ekhtiari YS. Socio-demographic determinants of obesity indexes in Iran: findings from a nationwide STEPS survey. Health Promot Perspect 2018;8(3):187–94.

Yasmin I, Khan WA, Naz S, Iqbal MW, Awuchi CG, Egbuna C, et al. Etiology of Obesity, Cancer, and Diabetes. In: Egbuna C, Hassan S, (Eds). Dietary Phytochemicals. Cham: Springer; 2021.p. 1–27.

Yoo S. Syndrome M. Dynamic energy balance and obesity prevention. J Obes Metab Syndr 2018;27(4):203–12.

Gibbons C, Finlayson G, Dalton M, Caudwell P, Blundell JE. Metabolic phenotyping guidelines: studying eating behaviour in humans. J Endocrinol 2014;222(2):G1–12.

Cifuentes L, Acosta A. Homeostatic regulation of food intake. Clin Res Hepatol Gastroenterol 2022;46(2):101794.

Tack J, Verbeure W, Mori H, Schol J, Van den Houte K, Huang IH, et al. The gastrointestinal tract in hunger and satiety signalling. United European Gastroenterol J 2021;9(6):727–34.

Forde C, Van Kuijk N, Thaler T, de Graaf C, Martin N. Oral processing characteristics of solid savoury meal components, and relationship with food composition, sensory attributes and expected satiation. Appetite 2013;60:208–19.

Forde C, Van Kuijk N, Thaler T, De Graaf C, Martin N. Texture and savoury taste influences on food intake in a realistic hot lunch time meal. Appetite 2013;60:180–6.

Bolhuis DP, Forde CG, Cheng Y, Xu H, Martin N, de Graaf CJPo. Slow food: sustained impact of harder foods on the reduction in energy intake over the course of the day. PLoS One 2014;9(4):e93370.

Campbell CL, Wagoner TB, Foegeding EA JFS. Designing foods for satiety: The roles of food structure and oral processing in satiation and satiety. Food Structure 2017;13:1–12.

Pullicin AJ, Glendinning JI, Lim J. Cephalic phase insulin release: A review of its mechanistic basis and variability in humans. Physiol Behav 2021;239:113514.

Venegas C, Farfan Beltrán N, Bucchi C, Martínez Gomis J, Fuentes RJ. Effect of chewing behavior modification on food intake, appetite and satiety-related hormones: A Systematic Review. Rev Chil Nutr 2022;49(6):760–74.

Slyper A, Oral processing, satiation and obesity: overview and hypotheses. Diabetes Metab Syndr Obes 2021:3399–415.

Argyrakopoulou G, Simati S, Dimitriadis G, Kokkinos AJN. How important is eating rate in the physiological response to food intake, control of body weight, and glycemia? Nutrients 2020;12(6):1734.

Zhu Y, Hsu WH, Hollis JH. Increasing the number of masticatory cycles is associated with reduced appetite and altered postprandial plasma concentrations of gut hormones, insulin and glucose. Br J Nutr 2013;110(2):384–90.

Goh AT, Choy JYM, Chua XH, Ponnalagu S, Khoo CM, Whitton C, et al. Increased oral processing and a slower eating rate increase glycaemic, insulin and satiety responses to a mixed meal tolerance test. Eur J Nutr 2021;60(5):2719–33.

Simon SL, Pan Z, Marden T, Zhou W, Ghosh T, Hossain D, et al. Body mass index and variability in meal duration and association with rate of eating. Front Nutr 2022;9:941001.

Alsalim W, Ahrén B. Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects. Endocrinol Diabetes Metab 2019;2(2):e00056.

Sonoki K, Iwase M, Takata Y, Nakamoto T, Masaki C, Hosokawa R, et al. Effects of thirty-times chewing per bite on secretion of glucagon-like peptide-1 in healthy volunteers and type 2 diabetic patients. Endocr J 2013;60(3):311–9.

Cassady BA, Hollis JH, Fulford AD, Considine RV, Mattes RD. Mastication of almonds: effects of lipid bioaccessibility, appetite, and hormone response. Am J Clin Nutr 2009;89(3):794–800.

Kokkinos A, le Roux CW, Alexiadou K, Tentolouris N, Vincent RP, Kyriaki D, et al. Eating slowly increases the postprandial response of the anorexigenic gut hormones, peptide YY and glucagon-like peptide-1. J Clin Endocrinol Metab 2010;95:333–7.

Nauck MA, Vardarli I, Deacon CF, Holst JJ, Meier JJ. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia 2011;54(1):10–8.

Rijkelijkhuizen JM, McQuarrie K, Girman CJ, Stein PP, Mari A, Holst JJ, et al. Effects of meal size and composition on incretin, ?-cell, and ?-cell responses. Metabolism 2010;59(4):502–11.

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Published

30-06-2024

How to Cite

1.
Sardar A, Shah I, Malik O, Mahmood R, Asmatullah A, Qaisar O. EFFECTS OF CHEWING TIME OF HIGH PROTEIN MEAL ON SATIETY AND GLP-1 HORMONE. Pak J Phsyiol [Internet]. 2024 Jun. 30 [cited 2024 Jul. 21];20(2):31-5. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1632