PLASMA PROLIDASE ACTIVITY AND ITS RELATION WITH NUMBER OF CYSTS IN POLYCYSTIC OVARY SYNDROME

Authors

  • Murk Fatima Department of Physiology, Ziauddin University, Karachi, Pakistan https://orcid.org/0000-0002-2108-4894
  • Sofia Amjad Department of Physiology, Azra Naheed Medical College, Lahore, Pakistan https://orcid.org/0000-0003-1570-1304
  • Mehreen Inam Illahi Department of Physiology, Ziauddin University, Karachi, Pakistan https://orcid.org/0000-0003-4174-0999
  • Tousif Ahmed Department of Physiology, Ziauddin University, Karachi, Pakistan
  • Humaira Ansari Ziauddin College of Rehabilation Sciences, Karachi, Pakistan
  • Rehana Rehman Department of biological and biomedical sciences, Aga khan university, Karachi, Pakistan

DOI:

https://doi.org/10.69656/pjp.v20i2.1617

Keywords:

Phenotypes,, Extracellular matrix, Prolidase, Cysts, Polycystic ovaries, Syndrome

Abstract

Background: Plasma prolidase, a Matrix Metalloproteinase (MMP), has a role in maintaining extracellular matrix remodelling in ovary. The aim of this study was to find out the activity and association with the clinical and biochemical parameters of plasma prolidase in different phenotypes of Polycystic Ovary Syndrome (PCOS). Methods: Total 90 women (16-22 years) with PCOS were enrolled in the study. Data regarding anthropometric measurements (weight, height, BMI and WHR) were taken. Transabdominal ultrasonography was done by trained sonographer. Hormonal tests (free testosterone, FSH, LH), and metabolic tests (including FBS) were done by chemiluminescence analyzer. Participants were divided into four groups. Group 1 (n=25), hyperandrogenism with oligo-anovulation (HO), Group 2 (n=26), polycystic ovary with oligo-anovulation (PO), Group 3 (n=20), hyperandrogenism with polycystic ovary (HP), Group 4 (n=19), with presence of all these three features (PHO). Five ml blood sample was taken for plasma Prolidase by Spectrophotometry. Kruskal Wallis test and spearman correlation were used for statistical analysis. Results: Among 90 women 52.2% had both polycystic ovaries, 13.3% has one polycystic ovary and 34.4% had normal ovaries on ultrasound. Median difference of plasma Prolidase, LH, FSH, free testosterone and HOMA-IR between groups were found statistically significant (p<0.05). Plasma Prolidase had a direct relation (r=0.374) with number of cysts on ultrasound. Conclusion: Plasma Prolidase activity was high in PCOS phenotypes and positive correlation was found between Prolidase levels and number of cysts. Prolidase can be used as diagnostic and prognostic marker in PCOS.

Pak J Physiol 2024;20(2):14-8

Downloads

Download data is not yet available.

Author Biographies

Murk Fatima, Department of Physiology, Ziauddin University, Karachi, Pakistan

my idd are two

murk.fatima@zu.edu.pk

doc.murk.shaikh@gmail.com

Sofia Amjad, Department of Physiology, Azra Naheed Medical College, Lahore, Pakistan

Ph. D Physiology, Professor of Department of Physiology, Azra medical college, Lahore, Pakistan

Mehreen Inam Illahi, Department of Physiology, Ziauddin University, Karachi, Pakistan

Assistant Professor in Department of Physiology, Ziauddin University, Karachi, Pakistan

Tousif Ahmed, Department of Physiology, Ziauddin University, Karachi, Pakistan

Head of Department of Physiology, Ziauddin University, Karachi, Pakistan

Humaira Ansari, Ziauddin College of Rehabilation Sciences, Karachi, Pakistan

 Senior lecturer in Ziauddin college of rehabilation science

Rehana Rehman, Department of biological and biomedical sciences, Aga khan university, Karachi, Pakistan

Ph. D Physiology, FHEA (UK), MHPE

Professor and Director Graduates Studies, Department of biological and biomedical sciences, Aga khan university, Karachi

Downloads

Published

30-06-2024

How to Cite

1.
Fatima M, Amjad S, Inam Illahi M, Ahmed T, Ansari H, Rehman R. PLASMA PROLIDASE ACTIVITY AND ITS RELATION WITH NUMBER OF CYSTS IN POLYCYSTIC OVARY SYNDROME. Pak J Phsyiol [Internet]. 2024 Jun. 30 [cited 2024 Jul. 20];20(2):14-8. Available from: https://pjp.pps.org.pk/index.php/PJP/article/view/1617