ANTI-MÜLLERIAN HORMONE: A BETTER BIO MARKER FOR ASSESSMENT OF ANOVULATION IN POLYCYSTIC OVARIAN SYNDROME COMPARED TO CONVENTIONAL BIOMARKERS
Keywords:
Anti-Mullerian hormone, Polycystic ovarian syndrome, SensitivityAbstract
Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women of childbearing age. The objective of this study was to determine the diagnostic accuracy of Anti-Müllerian Hormone (AMH) in predicting anovulatory PCOS, keeping day 21 progesterone level as gold standard. Methods: This cross-sectional validation study was conducted on 289 women aged 15–30 years with PCOS, from 11 Aug 2021 to 10 Feb 2022, in Pathology Department, Bahawal Victoria Hospital, Bahawalpur. AMH levels were measured and anovulatory events documented. AMH levels were compared with progesterone levels on the 21st day of the menstrual cycle. Results: In the cohort of individuals demonstrating a positive presence of AMH, a total of 149 were accurately identified as true positives, while 6 were mistakenly classified as false positives. Within the group of patients exhibiting a negative status for AMH, 8 were incorrectly categorized as false negatives, whereas 126 were correctly identified as true negatives. When evaluating the diagnostic efficacy of AMH as a predictor of anovulatory PCOS, with the 21st day progesterone measurement, the following metrics were ascertained: a commendable sensitivity of 94.90%, a robust specificity of 95.45%, a notable positive predictive value of 96.13%, a substantial negative predictive value of 94.03%, and an impressive overall diagnostic accuracy of 95.16%. Conclusion: The diagnostic accuracy of Anti-Müllerian hormone in predicting anovulatory PCOS is very high.
Pak J Physiol 2024;20(1):8-11
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